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Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects.
Eiken AP, Smith AL, Skupa SA, Schmitz E, Rana S, Singh S, Kumar S, Mallareddy JR, de Cubas AA, Krishna A, Kalluchi A, Rowley MJ, D'Angelo CR, Lunning MA, Bociek RG, Vose JM, Natarajan A, El-Gamal D. Eiken AP, et al. Among authors: smith al. Cancer Res Commun. 2024 May 22;4(5):1328-1343. doi: 10.1158/2767-9764.CRC-24-0071. Cancer Res Commun. 2024. PMID: 38687198 Free PMC article.
Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
Vann KR, Acharya A, Jang SM, Lachance C, Zandian M, Holt TA, Smith AL, Pandey K, Durden DL, El-Gamal D, Côté J, Byrareddy SN, Kutateladze TG. Vann KR, et al. Among authors: smith al. Structure. 2022 Sep 1;30(9):1224-1232.e5. doi: 10.1016/j.str.2022.05.020. Epub 2022 Jun 17. Structure. 2022. PMID: 35716662 Free PMC article.
BET inhibition reforms the immune microenvironment and alleviates T cell dysfunction in chronic lymphocytic leukemia.
Smith AL, Skupa SA, Eiken AP, Reznicek TE, Schmitz E, Williams N, Moore DY, D'Angelo CR, Kallam A, Lunning MA, Bociek RG, Vose JM, Mohamed E, Mahr AR, Denton PW, Powell B, Bollag G, Rowley MJ, El-Gamal D. Smith AL, et al. JCI Insight. 2024 May 22;9(10):e177054. doi: 10.1172/jci.insight.177054. JCI Insight. 2024. PMID: 38775157 Free PMC article.
TLR9 agonism differentially impacts human NK cell-mediated direct killing and antibody-dependent cell-mediated cytotoxicity.
Mahr AR, Bennett-Boehm MMC, Rothemejer FH, Weber IS, Regan AK, Franzen JQ, Bisson CR, Truong AN, Olesen R, Schleimann MH, Rauter CM, Smith AL, El-Gamal D, Søgaard OS, Tolstrup M, Denton PW. Mahr AR, et al. Among authors: smith al. Sci Rep. 2024 Jun 25;14(1):14595. doi: 10.1038/s41598-024-65576-2. Sci Rep. 2024. PMID: 38918496 Free PMC article.
1,368 results