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A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity.
Al Assi A, Posty S, Lamarche F, Chebel A, Guitton J, Cottet-Rousselle C, Prudent R, Lafanechère L, Giraud S, Dallemagne P, Suzanne P, Verney A, Genestier L, Castets M, Fontaine E, Billaud M, Cordier-Bussat M. Al Assi A, et al. Among authors: guitton j. Cell Death Dis. 2024 May 2;15(5):311. doi: 10.1038/s41419-024-06668-9. Cell Death Dis. 2024. PMID: 38697987 Free PMC article.
The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor.
Lacombe ML, Lamarche F, De Wever O, Padilla-Benavides T, Carlson A, Khan I, Huna A, Vacher S, Calmel C, Desbourdes C, Cottet-Rousselle C, Hininger-Favier I, Attia S, Nawrocki-Raby B, Raingeaud J, Machon C, Guitton J, Le Gall M, Clary G, Broussard C, Chafey P, Thérond P, Bernard D, Fontaine E, Tokarska-Schlattner M, Steeg P, Bièche I, Schlattner U, Boissan M. Lacombe ML, et al. Among authors: guitton j. BMC Biol. 2021 Oct 21;19(1):228. doi: 10.1186/s12915-021-01155-5. BMC Biol. 2021. PMID: 34674701 Free PMC article.
Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance.
Therizols G, Bash-Imam Z, Panthu B, Machon C, Vincent A, Ripoll J, Nait-Slimane S, Chalabi-Dchar M, Gaucherot A, Garcia M, Laforêts F, Marcel V, Boubaker-Vitre J, Monet MA, Bouclier C, Vanbelle C, Souahlia G, Berthel E, Albaret MA, Mertani HC, Prudhomme M, Bertrand M, David A, Saurin JC, Bouvet P, Rivals E, Ohlmann T, Guitton J, Dalla Venezia N, Pannequin J, Catez F, Diaz JJ. Therizols G, et al. Among authors: guitton j. Nat Commun. 2022 Jan 10;13(1):173. doi: 10.1038/s41467-021-27847-8. Nat Commun. 2022. PMID: 35013311 Free PMC article.
Autocrine Adenosine Regulates Tumor Polyfunctional CD73+CD4+ Effector T Cells Devoid of Immune Checkpoints.
Gourdin N, Bossennec M, Rodriguez C, Vigano S, Machon C, Jandus C, Bauché D, Faget J, Durand I, Chopin N, Tredan O, Marie JC, Dubois B, Guitton J, Romero P, Caux C, Ménétrier-Caux C. Gourdin N, et al. Among authors: guitton j. Cancer Res. 2018 Jul 1;78(13):3604-3618. doi: 10.1158/0008-5472.CAN-17-2405. Epub 2018 Mar 20. Cancer Res. 2018. PMID: 29559470 Free article.
204 results