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Challenges and Opportunities for In Vitro-In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation.
Izat N, Bolleddula J, Abbasi A, Cheruzel L, Jones RS, Moss D, Ortega-Muro F, Parmentier Y, Peterkin VC, Tian DD, Venkatakrishnan K, Zientek MA, Barber J, Houston JB, Galetin A, Scotcher D. Izat N, et al. Among authors: jones rs. Drug Metab Dispos. 2023 Dec;51(12):1591-1606. doi: 10.1124/dmd.123.001436. Epub 2023 Sep 26. Drug Metab Dispos. 2023. PMID: 37751998
Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates.
Izat N, Bolleddula J, Carione P, Huertas Valentin L, Jones RS, Kulkarni P, Moss D, Peterkin VC, Tian DD, Treyer A, Venkatakrishnan K, Zientek MA, Barber J, Houston JB, Galetin A, Scotcher D. Izat N, et al. Among authors: jones rs. CPT Pharmacometrics Syst Pharmacol. 2024 Oct 23. doi: 10.1002/psp4.13255. Online ahead of print. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 39444174 Free article.
Analysis of the Bile Acid Composition in a Fibroblast Growth Factor 19-Expressing Liver-Humanized Mouse Model and Its Use for CYP3A4-Mediated Drug-Drug Interaction Studies.
Mezler M, Jones RS, Sangaraju D, Goldman DC, Hoffmann M, Heikkinen AT, Mannila J, Chang JH, Foquet L, Pusalkar S, Chothe PP, Scheer N. Mezler M, et al. Among authors: jones rs. Drug Metab Dispos. 2023 Oct;51(10):1391-1402. doi: 10.1124/dmd.123.001398. Epub 2023 Jul 31. Drug Metab Dispos. 2023. PMID: 37524541
808 results