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A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice.
Wolf K, Kühn H, Boehm F, Gebhardt L, Glaudo M, Agelopoulos K, Ständer S, Ectors P, Zahn D, Riedel YK, Thimm D, Müller CE, Kretschmann S, Kremer AN, Chien D, Limjunyawong N, Peng Q, Dong X, Kolkhir P, Scheffel J, Søgaard ML, Weigmann B, Neurath MF, Hawro T, Metz M, Fischer MJM, Kremer AE. Wolf K, et al. J Allergy Clin Immunol. 2021 Aug;148(2):506-522.e8. doi: 10.1016/j.jaci.2020.12.655. Epub 2021 Feb 20. J Allergy Clin Immunol. 2021. PMID: 33617860
Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions.
Zaufel A, van de Wiel SMW, Yin L, Fauler G, Chien D, Dong X, Gilmer JF, Truong JK, Dawson PA, van de Graaf SFJ, Fickert P, Moustafa T. Zaufel A, et al. Biochim Biophys Acta Mol Basis Dis. 2021 Aug 1;1867(8):166153. doi: 10.1016/j.bbadis.2021.166153. Epub 2021 Apr 22. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 33895309 Free PMC article.
Molecular Display of the Animal Meta-Venome for Discovery of Novel Therapeutic Peptides.
Hsiao MH, Miao Y, Liu Z, Schütze K, Limjunyawong N, Chien DC, Monteiro WD, Chu LS, Morgenlander W, Jayaraman S, Jang SE, Gray JJ, Zhu H, Dong X, Steinegger M, Larman HB. Hsiao MH, et al. Among authors: chien dc. bioRxiv [Preprint]. 2024 May 28:2024.05.27.595990. doi: 10.1101/2024.05.27.595990. bioRxiv. 2024. Update in: Mol Cell Proteomics. 2024 Dec 31:100901. doi: 10.1016/j.mcpro.2024.100901 PMID: 38854075 Free PMC article. Updated. Preprint.