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871 results

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Page 1
Antigenic determinants underlying IgE-mediated anaphylaxis to peanut.
Smith SA, Khan YW, Shrem RA, Hemler JA, Doyle JE, Daniel J, Zhang J, Pena-Amelunxen G, Aglas L, Hamilton RG, Getts R, Sampson HA, Wong JJW, Croote D, Peebles RS Jr, Spiller BW. Smith SA, et al. J Allergy Clin Immunol. 2025 Jan 13:S0091-6749(25)00018-1. doi: 10.1016/j.jaci.2024.12.1094. Online ahead of print. J Allergy Clin Immunol. 2025. PMID: 39814145
RESULTS: We created a large panel of 54 peanut-specific IgE mAbs, of which 63% were specific for Ara h 2 and/or 6. Pairs of IgE mAbs with the same antigen-specificity but different binding sites were able to mediate passive systemic anaphylaxis in FcepsilonRI transg …
RESULTS: We created a large panel of 54 peanut-specific IgE mAbs, of which 63% were specific for Ara h 2 and/or 6. Pairs of Ig …
Structural determinants of peanut induced anaphylaxis.
Smith SA, Shrem RA, Lança BBC, Zhang J, Wong JJW, Croote D, Peebles RS Jr, Spiller BW. Smith SA, et al. J Allergy Clin Immunol. 2025 Jan 11:S0091-6749(25)00019-3. doi: 10.1016/j.jaci.2024.12.1095. Online ahead of print. J Allergy Clin Immunol. 2025. PMID: 39805366
METHODS: We identified candidates from a panel of epitope binned human IgE monoclonals that recognize two important and homologous peanut allergens, Ara h 2 and Ara h 6. Crystal structures were determined revealing the interfaces (antigenic sites) of e …
METHODS: We identified candidates from a panel of epitope binned human IgE monoclonals that recognize two important and homologous peanut al …
Prophylactic Peanut Allergen Ara h 6 Sublingual Immunotherapy Drives Expansion of FoxP3(+)Helios(-) Regulatory T Cells in the Absence of Allergen-Specific IgA.
Larsen JM, Lundsgaard EA, Danneskiold-Samsøe NB, Sonne SB, Rigby NM, Mackie AR, Kristiansen K, Bøgh KL. Larsen JM, et al. Immunology. 2025 Jan 7. doi: 10.1111/imm.13883. Online ahead of print. Immunology. 2025. PMID: 39777617
BN rats received daily sublingual administration of peanut allergen Ara h 6 for three weeks. Suppression of sensitisation was evaluated by subsequent intraperitoneal administration of Ara h 6. ...The sublingual tissue response to Ara h 6 …
BN rats received daily sublingual administration of peanut allergen Ara h 6 for three weeks. Suppression of sensitisation was …
Ara h 2-expressing cucumber mosaic virus-like particle (VLP Peanut) induces in vitro tolerogenic cellular responses in peanut-allergic individuals.
Layhadi JA, Starchenka S, De Kam PJ, Palmer E, Patel N, Keane ST, Hikmawati P, Drazdauskaite G, Wu LYD, Filipaviciute P, Parkin RV, Oluwayi K, Rusyn O, Skinner MA, Heath MD, Hewings SJ, Kramer MF, Turner P, Shamji MH. Layhadi JA, et al. J Allergy Clin Immunol. 2025 Jan;155(1):153-165. doi: 10.1016/j.jaci.2024.08.010. J Allergy Clin Immunol. 2025. PMID: 39756833
Modulation of dendritic cells (DCs), T cells, and B cells, stimulated with VLP Peanut, Ara h 2, and whole peanut extract in vitro, were assessed by quantitative real-time PCR and flow cytometry, respectively. ...Moreover, VLP Peanut is associated with upregulation o …
Modulation of dendritic cells (DCs), T cells, and B cells, stimulated with VLP Peanut, Ara h 2, and whole peanut extract in vi …
M13 bacteriophage based fluorescence immunoassay against food allergens of Ara h 3 and Mac i 1.
Wang Y, Wu S, Wang H, Huang X, Ji X, Lv H, Wu J, Liu J, Muyldermans S, Hu Y, Wang S. Wang Y, et al. Food Chem. 2024 Dec 24;469:142617. doi: 10.1016/j.foodchem.2024.142617. Online ahead of print. Food Chem. 2024. PMID: 39732076
The nanobodies (Nbs) displayed on M13 bacteriophage were employed for the rapid fluorescence quantification of peanut allergen Ara h 3 and macadamia allergen Mac i 1 through magnetic separation. Generally, the method was established with detection limits of 9.5 and …
The nanobodies (Nbs) displayed on M13 bacteriophage were employed for the rapid fluorescence quantification of peanut allergen Ara …
Diagnostic Accuracy of Lipid Transfer Proteins (LTPs) Specific IgE Assay in Food Allergy: A Systematic Review.
Bellia C, Sardina DS, Scazzone C, Lio D, Scola L, Uasuf CG. Bellia C, et al. Int J Mol Sci. 2024 Dec 1;25(23):12925. doi: 10.3390/ijms252312925. Int J Mol Sci. 2024. PMID: 39684636 Free PMC article. Review.
Fifteen articles, including 2395 individuals, were included. The sensitivity of Ara h 9 for peanut allergy diagnosis ranged from 6 to 61%; the specificity ranged from 57 to 100%. The Cor a 8 sensitivity ranged from 11 to 43%, with the specificity ranging from 59 to …
Fifteen articles, including 2395 individuals, were included. The sensitivity of Ara h 9 for peanut allergy diagnosis ranged fr …
Evaluating clinical importance of sensitization to Ara h 6 quantitively in Japanese children.
Sato S, Yanagida N, Nagakura KI, Takahashi K, Borres MP, Ebisawa M. Sato S, et al. World Allergy Organ J. 2024 Nov 20;17(12):101001. doi: 10.1016/j.waojou.2024.101001. eCollection 2024 Dec. World Allergy Organ J. 2024. PMID: 39640895 Free PMC article.
Ara h 6 and Ara h 2 co-sensitization was observed in 224 patients (82%). Ara h 6-sIgE levels were significantly associated with the probability of allergic reactions and anaphylaxis. ...However, the measurement of Ara h 6 di …
Ara h 6 and Ara h 2 co-sensitization was observed in 224 patients (82%). Ara h 6-sIgE levels were …
The conformational epitope of Ara h 5 was crucial to the severe reactivity of peanut allergy.
Wang J, Hao M, Wang Q, Liu M, Liu G, Han S, Zhao X, Che H. Wang J, et al. Mol Immunol. 2024 Dec;176:11-21. doi: 10.1016/j.molimm.2024.10.004. Epub 2024 Nov 15. Mol Immunol. 2024. PMID: 39549640
Compared to Ara h 8, the conformational epitope of Ara h 5 protein was crucial in the process of sensitization. ...Ara h 5 caused more severe lung inflammation than Ara h 8 protein. While Ara h 8 caused more se …
Compared to Ara h 8, the conformational epitope of Ara h 5 protein was crucial in the process of sensitization. …
Baseline epitope-specific IgE profiles are predictive of sustained unresponsiveness or high threshold 1-year post oral immunotherapy in the POISED trial.
Suprun M, Lee ASE, Getts R, Peck S, Sindher SB, Nadeau KC, Chinthrajah RS, Galli SJ, Sampson HA. Suprun M, et al. J Allergy Clin Immunol. 2024 Nov 5:S0091-6749(24)01161-8. doi: 10.1016/j.jaci.2024.10.017. Online ahead of print. J Allergy Clin Immunol. 2024. PMID: 39505279
Specific IgE and IgG(4) levels to peanut; Ara h 1, Ara h 2, and Ara h 3 proteins; and 64 allergenic epitopes were measured. We developed machine learning models with bootstrap simulations using baseline data to predict SU/SHT. ...
Specific IgE and IgG(4) levels to peanut; Ara h 1, Ara h 2, and Ara h 3 proteins; and 64 allergeni …
871 results