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APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O. Yin Z, et al. Among authors: krishnan rk. Nat Immunol. 2023 Nov;24(11):1839-1853. doi: 10.1038/s41590-023-01627-6. Epub 2023 Sep 25. Nat Immunol. 2023. PMID: 37749326 Free PMC article.
Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease.
Rosenzweig N, Kleemann KL, Rust T, Carpenter M, Grucci M, Aronchik M, Brouwer N, Valenbreder I, Cooper-Hohn J, Iyer M, Krishnan RK, Sivanathan KN, Brandão W, Yahya T, Durao A, Yin Z, Chadarevian JP, Properzi MJ, Nowarski R, Davtyan H, Weiner HL, Blurton-Jones M, Yang HS, Eggen BJL, Sperling RA, Butovsky O. Rosenzweig N, et al. Among authors: krishnan rk. Nat Med. 2024 Oct;30(10):2990-3003. doi: 10.1038/s41591-024-03122-3. Epub 2024 Jul 3. Nat Med. 2024. PMID: 38961225
Transcription factor TCF1 binds to RORγt and orchestrates a regulatory network that determines homeostatic Th17 cell state.
Mangani D, Subramanian A, Huang L, Cheng H, Krovi SH, Wu Y, Yang D, Moreira TG, Escobar G, Schnell A, Dixon KO, Krishnan RK, Singh V, Sobel RA, Weiner HL, Kuchroo VK, Anderson AC. Mangani D, et al. Among authors: krishnan rk. Immunity. 2024 Nov 12;57(11):2565-2582.e6. doi: 10.1016/j.immuni.2024.09.017. Epub 2024 Oct 23. Immunity. 2024. PMID: 39447575
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells.
Thakore PI, Schnell A, Huang L, Zhao M, Hou Y, Christian E, Zaghouani S, Wang C, Singh V, Singaraju A, Krishnan RK, Kozoriz D, Ma S, Sankar V, Notarbartolo S, Buenrostro JD, Sallusto F, Patsopoulos NA, Rozenblatt-Rosen O, Kuchroo VK, Regev A. Thakore PI, et al. Among authors: krishnan rk. Nat Immunol. 2024 Aug;25(8):1395-1410. doi: 10.1038/s41590-024-01901-1. Epub 2024 Jul 15. Nat Immunol. 2024. PMID: 39009838
Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity.
Tooley K, Jerby L, Escobar G, Krovi SH, Mangani D, Dandekar G, Cheng H, Madi A, Goldschmidt E, Lambden C, Krishnan RK, Rozenblatt-Rosen O, Regev A, Anderson AC. Tooley K, et al. Among authors: krishnan rk. Cell Rep Med. 2024 Jul 16;5(7):101640. doi: 10.1016/j.xcrm.2024.101640. Epub 2024 Jul 2. Cell Rep Med. 2024. PMID: 38959885 Free PMC article.
Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy.
Escobar G, Tooley K, Oliveras JP, Huang L, Cheng H, Bookstaver ML, Edwards C, Froimchuk E, Xue C, Mangani D, Krishnan RK, Hazel N, Rutigliani C, Jewell CM, Biasco L, Anderson AC. Escobar G, et al. Among authors: krishnan rk. Cancer Cell. 2023 Sep 11;41(9):1662-1679.e7. doi: 10.1016/j.ccell.2023.08.001. Epub 2023 Aug 24. Cancer Cell. 2023. PMID: 37625402 Free PMC article.
Bacillary Angiomatosis Mimicking Pyogenic Granuloma.
A RK, K N, Krishnan RK, Dinesh S, R R. A RK, et al. Among authors: krishnan rk. Cureus. 2023 Mar 29;15(3):e36844. doi: 10.7759/cureus.36844. eCollection 2023 Mar. Cureus. 2023. PMID: 37123686 Free PMC article.
40 results