Venkatakrishnan K - Search Results

1

Moving the Needle for Oncology Dose Optimization: A Call for Action.

Venkatakrishnan K, Jayachandran P, Seo SK, van der Graaf PH, Wagner JA, Gupta N. Venkatakrishnan K, et al. Clin Pharmacol Ther. 2024 Jun;115(6):1187-1197. doi: 10.1002/cpt.3263. Clin Pharmacol Ther. 2024. PMID: 38736240 No abstract available.

2

Metabolism and disposition of a gamma-aminobutyric acid type A receptor partial agonist in humans.

Shaffer CL, Gunduz M, Vaz AD, Venkatakrishnan K, Burstein AH. Shaffer CL, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2008 Apr;36(4):655-62. doi: 10.1124/dmd.107.019760. Epub 2008 Jan 7. Drug Metab Dispos. 2008. PMID: 18180269

3

Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man.

Venkatakrishnan K, von Moltke LL, Duan SX, Fleishaker JC, Shader RI, Greenblatt DJ. Venkatakrishnan K, et al. J Pharm Pharmacol. 1998 Mar;50(3):265-74. doi: 10.1111/j.2042-7158.1998.tb06859.x. J Pharm Pharmacol. 1998. PMID: 9600717

4

Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment.

Venkatakrishnan K, Obach RS, Rostami-Hodjegan A. Venkatakrishnan K, et al. Xenobiotica. 2007 Oct-Nov;37(10-11):1225-56. doi: 10.1080/00498250701670945. Xenobiotica. 2007. PMID: 17968744 Review.

5

Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures.

Venkatakrishnan K, Tseng E, Nelson FR, Rollema H, French JL, Kaplan IV, Horner WE, Gibbs MA. Venkatakrishnan K, et al. Drug Metab Dispos. 2007 Aug;35(8):1341-9. doi: 10.1124/dmd.106.013953. Epub 2007 Apr 30. Drug Metab Dispos. 2007. PMID: 17470526

6

Biotransformation of an alpha4beta2 nicotinic acetylcholine receptor partial agonist in sprague-dawley rats and the dispositional characterization of its N-carbamoyl glucuronide metabolite.

Shaffer CL, Ryder TF, Venkatakrishnan K, Henne IK, O'Connell TN. Shaffer CL, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2009 Jul;37(7):1480-9. doi: 10.1124/dmd.109.027037. Epub 2009 Apr 1. Drug Metab Dispos. 2009. PMID: 19339375

7

Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation.

Venkatakrishnan K, Obach RS. Venkatakrishnan K, et al. Curr Drug Metab. 2007 Jun;8(5):449-62. doi: 10.2174/138920007780866861. Curr Drug Metab. 2007. PMID: 17584016

8

Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro.

Greenblatt DJ, Venkatakrishnan K, Harmatz JS, Parent SJ, von Moltke LL. Greenblatt DJ, et al. Among authors: venkatakrishnan k. Xenobiotica. 2010 Oct;40(10):713-20. doi: 10.3109/00498254.2010.506224. Xenobiotica. 2010. PMID: 20712450 Review.

9

Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: a prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study.

Venkatakrishnan K, Rader M, Ramanathan RK, Ramalingam S, Chen E, Riordan W, Trepicchio W, Cooper M, Karol M, von Moltke L, Neuwirth R, Egorin M, Chatta G. Venkatakrishnan K, et al. Clin Ther. 2009;31 Pt 2:2444-58. doi: 10.1016/j.clinthera.2009.11.012. Clin Ther. 2009. PMID: 20110052 Clinical Trial.

10

Dose selection for the investigational anticancer agent alisertib (MLN8237): Pharmacokinetics, pharmacodynamics, and exposure-safety relationships.

Venkatakrishnan K, Zhou X, Ecsedy J, Mould DR, Liu H, Danaee H, Fingert H, Kleinfield R, Milton A. Venkatakrishnan K, et al. J Clin Pharmacol. 2015 Mar;55(3):336-47. doi: 10.1002/jcph.410. Epub 2014 Nov 18. J Clin Pharmacol. 2015. PMID: 25302940

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