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The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury.
Katerelos M, Gleich K, Harley G, Loh K, Oakhill JS, Kemp BE, de Souza DP, Narayana VK, Coughlan MT, Laskowski A, Ling NXY, Murray-Segal L, Brink R, Lee M, Power DA, Mount PF. Katerelos M, et al. Among authors: gleich k. Biomed Pharmacother. 2024 Jun;175:116730. doi: 10.1016/j.biopha.2024.116730. Epub 2024 May 14. Biomed Pharmacother. 2024. PMID: 38749175 Free article.
AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1.
Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows KR, Kemp BE, Power DA. Fraser SA, et al. Among authors: gleich k. Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F679-90. doi: 10.1152/ajprenal.00407.2012. Epub 2013 Jun 19. Am J Physiol Renal Physiol. 2013. PMID: 23785098 Free PMC article.
Activation of AMPK reduces the co-transporter activity of NKCC1.
Fraser SA, Davies M, Katerelos M, Gleich K, Choy SW, Steel R, Galic S, Mount PF, Kemp BE, Power DA. Fraser SA, et al. Among authors: gleich k. Mol Membr Biol. 2014 Mar-May;31(2-3):95-102. doi: 10.3109/09687688.2014.902128. Epub 2014 Apr 7. Mol Membr Biol. 2014. PMID: 24702155 Free article.
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