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The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury.
Katerelos M, Gleich K, Harley G, Loh K, Oakhill JS, Kemp BE, de Souza DP, Narayana VK, Coughlan MT, Laskowski A, Ling NXY, Murray-Segal L, Brink R, Lee M, Power DA, Mount PF. Katerelos M, et al. Among authors: murray segal l. Biomed Pharmacother. 2024 Jun;175:116730. doi: 10.1016/j.biopha.2024.116730. Epub 2024 May 14. Biomed Pharmacother. 2024. PMID: 38749175 Free article.
Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism.
Hoffman NJ, Whitfield J, Janzen NR, Belhaj MR, Galic S, Murray-Segal L, Smiles WJ, Ling NXY, Dite TA, Scott JW, Oakhill JS, Brink R, Kemp BE, Hawley JA. Hoffman NJ, et al. Among authors: murray segal l. Mol Metab. 2020 Nov;41:101048. doi: 10.1016/j.molmet.2020.101048. Epub 2020 Jun 29. Mol Metab. 2020. PMID: 32610071 Free PMC article.
Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.
Neopane K, Kozlov N, Negoita F, Murray-Segal L, Brink R, Hoque A, Ovens AJ, Tjin G, McAloon LM, Yu D, Ling NXY, Sanders MJ, Oakhill JS, Scott JW, Steinberg GR, Loh K, Kemp BE, Sakamoto K, Galic S. Neopane K, et al. Among authors: murray segal l. Cell Rep. 2022 Dec 20;41(12):111862. doi: 10.1016/j.celrep.2022.111862. Cell Rep. 2022. PMID: 36543129 Free article.
An AMPKα2-specific phospho-switch controls lysosomal targeting for activation.
Morrison KR, Smiles WJ, Ling NXY, Hoque A, Shea G, Ngoei KRW, Yu D, Murray-Segal L, Scott JW, Galic S, Kemp BE, Petersen J, Oakhill JS. Morrison KR, et al. Among authors: murray segal l. Cell Rep. 2022 Feb 15;38(7):110365. doi: 10.1016/j.celrep.2022.110365. Cell Rep. 2022. PMID: 35172150 Free article.
ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways.
Lee HJ, Moon J, Chung I, Chung JH, Park C, Lee JO, Han JA, Kang MJ, Yoo EH, Kwak SY, Jo G, Park W, Park J, Kim KM, Lim S, Ngoei KRW, Ling NXY, Oakhill JS, Galic S, Murray-Segal L, Kemp BE, Mantzoros CS, Krauss RM, Shin MJ, Kim HS. Lee HJ, et al. Among authors: murray segal l. FASEB J. 2019 Dec;33(12):14825-14840. doi: 10.1096/fj.201901440RR. Epub 2019 Oct 31. FASEB J. 2019. PMID: 31670977
The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2.
Lee JO, Byun WS, Kang MJ, Han JA, Moon J, Shin MJ, Lee HJ, Chung JH, Lee JS, Son CG, Song KH, Kim TW, Lee ES, Kim HM, Chung CH, Ngoei KRW, Ling NXY, Oakhill JS, Galic S, Murray-Segal L, Kemp BE, Kim KM, Lim S, Kim HS. Lee JO, et al. Among authors: murray segal l. FEBS J. 2020 May;287(10):2087-2104. doi: 10.1111/febs.15301. Epub 2020 Apr 19. FEBS J. 2020. PMID: 32196931 Free PMC article.
Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance.
Loh K, Tam S, Murray-Segal L, Huynh K, Meikle PJ, Scott JW, van Denderen B, Chen Z, Steel R, LeBlond ND, Burkovsky LA, O'Dwyer C, Nunes JRC, Steinberg GR, Fullerton MD, Galic S, Kemp BE. Loh K, et al. Among authors: murray segal l. Hepatol Commun. 2018 Nov 12;3(1):84-98. doi: 10.1002/hep4.1279. eCollection 2019 Jan. Hepatol Commun. 2018. PMID: 30619997 Free PMC article.
39 results