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Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy.
Xia M, Varmazyad M, Pla-Palacín I, Gavlock DC, DeBiasio R, LaRocca G, Reese C, Florentino RM, Faccioli LAP, Brown JA, Vernetti LA, Schurdak M, Stern AM, Gough A, Behari J, Soto-Gutierrez A, Taylor DL, Miedel MT. Xia M, et al. Among authors: varmazyad m. Front Cell Dev Biol. 2024 Sep 11;12:1423936. doi: 10.3389/fcell.2024.1423936. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39324073 Free PMC article.
Ketogenic diet induces p53-dependent cellular senescence in multiple organs.
Wei SJ, Schell JR, Chocron ES, Varmazyad M, Xu G, Chen WH, Martinez GM, Dong FF, Sreenivas P, Trevino R Jr, Jiang H, Du Y, Saliba A, Qian W, Lorenzana B, Nazarullah A, Chang J, Sharma K, Munkácsy E, Horikoshi N, Gius D. Wei SJ, et al. Among authors: varmazyad m. Sci Adv. 2024 May 17;10(20):eado1463. doi: 10.1126/sciadv.ado1463. Epub 2024 May 17. Sci Adv. 2024. PMID: 38758782 Free PMC article.
Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease.
Xu G, Quan S, Schell J, Gao Y, Varmazyad M, Sreenivas P, Cruz D, Jiang H, Pan M, Han X, Palavicini JP, Zhao P, Sun X, Marchant ED, Rasmussen BB, Li G, Katsumura S, Morita M, Munkácsy E, Horikoshi N, Chocron ES, Gius D. Xu G, et al. Among authors: varmazyad m. Sci Adv. 2024 May 17;10(20):eadj5942. doi: 10.1126/sciadv.adj5942. Epub 2024 May 17. Sci Adv. 2024. PMID: 38758779 Free PMC article.
Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy.
Xia M, Varmazyad M, Palacin IP, Gavlock DC, Debiasio R, LaRocca G, Reese C, Florentino R, Faccioli LAP, Brown JA, Vernetti LA, Schurdak ME, Stern AM, Gough A, Behari J, Soto-Gutierrez A, Taylor DL, Miedel M. Xia M, et al. Among authors: varmazyad m. bioRxiv [Preprint]. 2024 May 7:2024.04.22.590608. doi: 10.1101/2024.04.22.590608. bioRxiv. 2024. Update in: Front Cell Dev Biol. 2024 Sep 11;12:1423936. doi: 10.3389/fcell.2024.1423936 PMID: 38712213 Free PMC article. Updated. Preprint.