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Ketogenic diet induces p53-dependent cellular senescence in multiple organs.
Wei SJ, Schell JR, Chocron ES, Varmazyad M, Xu G, Chen WH, Martinez GM, Dong FF, Sreenivas P, Trevino R Jr, Jiang H, Du Y, Saliba A, Qian W, Lorenzana B, Nazarullah A, Chang J, Sharma K, Munkácsy E, Horikoshi N, Gius D. Wei SJ, et al. Among authors: chang j. Sci Adv. 2024 May 17;10(20):eado1463. doi: 10.1126/sciadv.ado1463. Epub 2024 May 17. Sci Adv. 2024. PMID: 38758782 Free PMC article.
NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression.
Reddy T, Puri A, Guzman-Rojas L, Thomas C, Qian W, Zhou J, Zhao H, Mahboubi B, Oo A, Cho YJ, Kim B, Thaiparambil J, Rosato R, Martinez KO, Chervo MF, Ayerbe C, Giese N, Wink D, Lockett S, Wong S, Chang J, Krishnamurthy S, Yam C, Moulder S, Piwnica-Worms H, Meric-Bernstam F, Chang J. Reddy T, et al. Among authors: chang j. Nat Commun. 2024 Dec 30;15(1):10737. doi: 10.1038/s41467-024-54651-x. Nat Commun. 2024. PMID: 39737957 Free PMC article.
Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1.
Choi DS, Blanco E, Kim YS, Rodriguez AA, Zhao H, Huang TH, Chen CL, Jin G, Landis MD, Burey LA, Qian W, Granados SM, Dave B, Wong HH, Ferrari M, Wong ST, Chang JC. Choi DS, et al. Stem Cells. 2014 Sep;32(9):2309-23. doi: 10.1002/stem.1746. Stem Cells. 2014. PMID: 24809620 Free PMC article.
Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer.
Dávila-González D, Choi DS, Rosato RR, Granados-Principal SM, Kuhn JG, Li WF, Qian W, Chen W, Kozielski AJ, Wong H, Dave B, Chang JC. Dávila-González D, et al. Among authors: chang jc. Clin Cancer Res. 2018 Mar 1;24(5):1152-1162. doi: 10.1158/1078-0432.CCR-17-1437. Epub 2018 Jan 4. Clin Cancer Res. 2018. PMID: 29301832 Free article.
ANETT: PhAse II trial of NEoadjuvant TAK-228 plus Tamoxifen in patients with hormone receptor-positive breast cancer.
Koca E, Niravath PA, Ensor J, Patel TA, Li X, Hemati P, Wong H, Qian W, Boone T, Zhao J, Ramshesh PV, Cohen AL, Murthy A, Nair S, Darcourt JG, Belcheva A, Kaklamani VG, Chang JCN. Koca E, et al. Among authors: chang jcn. Breast Cancer Res Treat. 2021 Jul;188(2):433-439. doi: 10.1007/s10549-021-06214-7. Epub 2021 Apr 15. Breast Cancer Res Treat. 2021. PMID: 33860388 Clinical Trial.
A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer.
Chung AW, Anand K, Anselme AC, Chan AA, Gupta N, Venta LA, Schwartz MR, Qian W, Xu Y, Zhang L, Kuhn J, Patel T, Rodriguez AA, Belcheva A, Darcourt J, Ensor J, Bernicker E, Pan PY, Chen SH, Lee DJ, Niravath PA, Chang JC. Chung AW, et al. Among authors: chang jc. Sci Transl Med. 2021 Dec 15;13(624):eabj5070. doi: 10.1126/scitranslmed.abj5070. Epub 2021 Dec 15. Sci Transl Med. 2021. PMID: 34910551 Clinical Trial.
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