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TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease.
Qin Y, Chen L, Zhu W, Song J, Lin J, Li Y, Zhang J, Song X, Xing T, Guo T, Duan X, Zhang Y, Ruan E, Wang Q, Li B, Yang W, Yin P, Yan XX, Li S, Li XJ, Yang S. Qin Y, et al. Among authors: song x, song j. Sci Adv. 2024 May 17;10(20):eadl2036. doi: 10.1126/sciadv.adl2036. Epub 2024 May 17. Sci Adv. 2024. PMID: 38758800 Free PMC article.
A Specific Mini-Intrabody Mediates Lysosome Degradation of Mutant Huntingtin.
Li C, Lin Y, Chen Y, Song X, Zheng X, Li J, He J, Chen X, Huang C, Wang W, Wu J, Wu J, Gao J, Tu Z, Li XJ, Yan S, Li S. Li C, et al. Among authors: song x. Adv Sci (Weinh). 2023 Nov;10(31):e2301120. doi: 10.1002/advs.202301120. Epub 2023 Sep 8. Adv Sci (Weinh). 2023. PMID: 37688357 Free PMC article.
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