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Centralized intestinal organoid generation is a feasible and safe approach for personalized medicine as demonstrated in the HIT-CF Europe Organoid Study.
Bierlaagh MC, van Mourik P, Vonk AM, Pott J, Muilwijk D, Berkers G, Aalbers BL, Vleggaar FP, Michel S, Boj SF, Vries RGJ, Beekman JM, van der Ent CK; HIT-CF organoid study group. Bierlaagh MC, et al. Among authors: vries rgj. J Cyst Fibros. 2024 Jul;23(4):703-706. doi: 10.1016/j.jcf.2024.04.016. Epub 2024 May 18. J Cyst Fibros. 2024. PMID: 38763840 Free article.
Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations.
de Winter-de Groot KM, Berkers G, Marck-van der Wilt REP, van der Meer R, Vonk A, Dekkers JF, Geerdink M, Michel S, Kruisselbrink E, Vries R, Clevers H, Vleggaar FP, Elias SG, Heijerman HGM, van der Ent CK, Beekman JM. de Winter-de Groot KM, et al. J Cyst Fibros. 2020 Jul;19(4):614-619. doi: 10.1016/j.jcf.2019.10.022. Epub 2019 Nov 15. J Cyst Fibros. 2020. PMID: 31735562 Free article.
Repeatability and reproducibility of the Forskolin-induced swelling (FIS) assay on intestinal organoids from people with Cystic Fibrosis.
Bierlaagh MC, Ramalho AS, Silva IAL, Vonk AM, van den Bor RM, van Mourik P, Pott J, Suen SWF, Boj SF, Vries RGJ, Lammertyn E, Vermeulen F, Amaral MD, de Boeck K, van der Ent CK, Beekman JM. Bierlaagh MC, et al. Among authors: vries rgj. J Cyst Fibros. 2024 Jul;23(4):693-702. doi: 10.1016/j.jcf.2024.04.014. Epub 2024 May 14. J Cyst Fibros. 2024. PMID: 38749892 Free article.
Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as a biomarker of CFTR function.
de Winter-de Groot KM, Janssens HM, van Uum RT, Dekkers JF, Berkers G, Vonk A, Kruisselbrink E, Oppelaar H, Vries R, Clevers H, Houwen RHJ, Escher JC, Elias SG, de Jonge HR, de Rijke YB, Tiddens HAWM, van der Ent CK, Beekman JM. de Winter-de Groot KM, et al. Eur Respir J. 2018 Sep 17;52(3):1702529. doi: 10.1183/13993003.02529-2017. Print 2018 Sep. Eur Respir J. 2018. PMID: 30166324 Free article.
Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis.
Berkers G, van Mourik P, Vonk AM, Kruisselbrink E, Dekkers JF, de Winter-de Groot KM, Arets HGM, Marck-van der Wilt REP, Dijkema JS, Vanderschuren MM, Houwen RHJ, Heijerman HGM, van de Graaf EA, Elias SG, Majoor CJ, Koppelman GH, Roukema J, Bakker M, Janssens HM, van der Meer R, Vries RGJ, Clevers HC, de Jonge HR, Beekman JM, van der Ent CK. Berkers G, et al. Among authors: vries rgj. Cell Rep. 2019 Feb 12;26(7):1701-1708.e3. doi: 10.1016/j.celrep.2019.01.068. Cell Rep. 2019. PMID: 30759382 Free article.
Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids.
Vonk AM, van Mourik P, Ramalho AS, Silva IAL, Statia M, Kruisselbrink E, Suen SWF, Dekkers JF, Vleggaar FP, Houwen RHJ, Mullenders J, Boj SF, Vries R, Amaral MD, de Boeck K, van der Ent CK, Beekman JM. Vonk AM, et al. STAR Protoc. 2020 Jun 3;1(1):100019. doi: 10.1016/j.xpro.2020.100019. eCollection 2020 Jun 19. STAR Protoc. 2020. PMID: 33111074 Free PMC article.
Lumacaftor/ivacaftor in people with cystic fibrosis with an A455E-CFTR mutation.
Berkers G, van der Meer R, Heijerman H, Beekman JM, Boj SF, Vries RGJ, van Mourik P, Doyle JR, Audhya P, Yuan ZJ, Kinnman N, van der Ent CK. Berkers G, et al. Among authors: vries rgj. J Cyst Fibros. 2021 Sep;20(5):761-767. doi: 10.1016/j.jcf.2020.11.007. Epub 2020 Nov 26. J Cyst Fibros. 2021. PMID: 33249003 Free article. Clinical Trial.
Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression.
Muilwijk D, de Poel E, van Mourik P, Suen SWF, Vonk AM, Brunsveld JE, Kruisselbrink E, Oppelaar H, Hagemeijer MC, Berkers G, de Winter-de Groot KM, Heida-Michel S, Jans SR, van Panhuis H, van der Eerden MM, van der Meer R, Roukema J, Dompeling E, Weersink EJM, Koppelman GH, Vries R, Zomer-van Ommen DD, Eijkemans MJC, van der Ent CK, Beekman JM. Muilwijk D, et al. Eur Respir J. 2022 Aug 18;60(2):2100508. doi: 10.1183/13993003.00508-2021. Print 2022 Aug. Eur Respir J. 2022. PMID: 35086832 Free PMC article.
Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier.
Jelinsky SA, Derksen M, Bauman E, Verissimo CS, van Dooremalen WTM, Roos JL, Higuera Barón C, Caballero-Franco C, Johnson BG, Rooks MG, Pott J, Oldenburg B, Vries RGJ, Boj SF, Kasaian MT, Pourfarzad F, Rosadini CV. Jelinsky SA, et al. Among authors: vries rgj. Inflamm Bowel Dis. 2023 Feb 1;29(2):195-206. doi: 10.1093/ibd/izac212. Inflamm Bowel Dis. 2023. PMID: 36356046 Free PMC article.
Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules.
Kourula S, Derksen M, Jardi F, Jonkers S, van Heerden M, Verboven P, Theuns V, Van Asten S, Huybrechts T, Kunze A, Frazer-Mendelewska E, Lai KW, Overmeer R, Roos JL, Vries RGJ, Boj SF, Monshouwer M, Pourfarzad F, Snoeys J. Kourula S, et al. Among authors: vries rgj. Eur J Pharm Sci. 2023 Sep 1;188:106481. doi: 10.1016/j.ejps.2023.106481. Epub 2023 May 25. Eur J Pharm Sci. 2023. PMID: 37244450 Free article.
48 results