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SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production.
Watanuki S, Kobayashi H, Sugiura Y, Yamamoto M, Karigane D, Shiroshita K, Sorimachi Y, Morikawa T, Fujita S, Shide K, Haraguchi M, Tamaki S, Mikawa T, Kondoh H, Nakano H, Sumiyama K, Nagamatsu G, Goda N, Okamoto S, Nakamura-Ishizu A, Shimoda K, Suematsu M, Suda T, Takubo K. Watanuki S, et al. Among authors: mikawa t. Cell Stem Cell. 2024 Aug 1;31(8):1145-1161.e15. doi: 10.1016/j.stem.2024.04.023. Epub 2024 May 20. Cell Stem Cell. 2024. PMID: 38772377
Dysregulated glycolysis as an oncogenic event.
Mikawa T, LLeonart ME, Takaori-Kondo A, Inagaki N, Yokode M, Kondoh H. Mikawa T, et al. Cell Mol Life Sci. 2015 May;72(10):1881-92. doi: 10.1007/s00018-015-1840-3. Epub 2015 Jan 22. Cell Mol Life Sci. 2015. PMID: 25609364 Free PMC article. Review.
Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer.
Itoyama R, Yasuda-Yoshihara N, Kitamura F, Yasuda T, Bu L, Yonemura A, Uchihara T, Arima K, Hu X, Jun Z, Okamoto Y, Akiyama T, Yamashita K, Nakao Y, Yusa T, Kitano Y, Higashi T, Miyata T, Imai K, Hayashi H, Yamashita YI, Mikawa T, Kondoh H, Baba H, Ishimoto T. Itoyama R, et al. Among authors: mikawa t. Cancer Lett. 2021 Dec 28;523:29-42. doi: 10.1016/j.canlet.2021.09.007. Epub 2021 Sep 9. Cancer Lett. 2021. PMID: 34508795
286 results