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JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase.
Bonneux B, Shareef A, Tcherniuk S, Anson B, de Bruyn S, Verheyen N, Thys K, Conceição-Neto N, Van Ginderen M, Kwanten L, Ysebaert N, Vranckx L, Peeters E, Lanckacker E, Gallup JM, Sitthicharoenchai P, Alnajjar S, Ackermann MR, Adhikary S, Bhaumik A, Patrick A, Fung A, Sutto-Ortiz P, Decroly E, Mason SW, Lançois D, Deval J, Jin Z, Eléouët JF, Fearns R, Koul A, Roymans D, Rigaux P, Herschke F. Bonneux B, et al. Among authors: jin z. Antiviral Res. 2024 Jul;227:105907. doi: 10.1016/j.antiviral.2024.105907. Epub 2024 May 19. Antiviral Res. 2024. PMID: 38772503 Free article.
Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection.
Wang G, Deval J, Hong J, Dyatkina N, Prhavc M, Taylor J, Fung A, Jin Z, Stevens SK, Serebryany V, Liu J, Zhang Q, Tam Y, Chanda SM, Smith DB, Symons JA, Blatt LM, Beigelman L. Wang G, et al. Among authors: jin z. J Med Chem. 2015 Feb 26;58(4):1862-78. doi: 10.1021/jm5017279. Epub 2015 Feb 10. J Med Chem. 2015. PMID: 25667954
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
Deval J, Hong J, Wang G, Taylor J, Smith LK, Fung A, Stevens SK, Liu H, Jin Z, Dyatkina N, Prhavc M, Stoycheva AD, Serebryany V, Liu J, Smith DB, Tam Y, Zhang Q, Moore ML, Fearns R, Chanda SM, Blatt LM, Symons JA, Beigelman L. Deval J, et al. Among authors: jin z. PLoS Pathog. 2015 Jun 22;11(6):e1004995. doi: 10.1371/journal.ppat.1004995. eCollection 2015 Jun. PLoS Pathog. 2015. PMID: 26098424 Free PMC article.
Structure of the Respiratory Syncytial Virus Polymerase Complex.
Gilman MSA, Liu C, Fung A, Behera I, Jordan P, Rigaux P, Ysebaert N, Tcherniuk S, Sourimant J, Eléouët JF, Sutto-Ortiz P, Decroly E, Roymans D, Jin Z, McLellan JS. Gilman MSA, et al. Among authors: jin z. Cell. 2019 Sep 19;179(1):193-204.e14. doi: 10.1016/j.cell.2019.08.014. Epub 2019 Sep 5. Cell. 2019. PMID: 31495574 Free PMC article.
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.
Yu X, Abeywickrema P, Bonneux B, Behera I, Anson B, Jacoby E, Fung A, Adhikary S, Bhaumik A, Carbajo RJ, De Bruyn S, Miller R, Patrick A, Pham Q, Piassek M, Verheyen N, Shareef A, Sutto-Ortiz P, Ysebaert N, Van Vlijmen H, Jonckers THM, Herschke F, McLellan JS, Decroly E, Fearns R, Grosse S, Roymans D, Sharma S, Rigaux P, Jin Z. Yu X, et al. Among authors: jin z. Commun Biol. 2023 Oct 21;6(1):1074. doi: 10.1038/s42003-023-05451-4. Commun Biol. 2023. PMID: 37865687 Free PMC article.
9,947 results