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Page 1
The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects.
Van Der Byl W, Nüssing S, Peters TJ, Ahn A, Li H, Ledergor G, David E, Koh AS, Wagle MV, Deguit CDT, de Menezes MN, Travers A, Sampurno S, Ramsbottom KM, Li R, Kallies A, Beavis PA, Jungmann R, Bastings MMC, Belz GT, Goel S, Trapani JA, Crabtree GR, Chang HY, Amit I, Goodnow CC, Luciani F, Parish IA. Van Der Byl W, et al. Among authors: nussing s. Immunity. 2024 Jun 11;57(6):1324-1344.e8. doi: 10.1016/j.immuni.2024.04.026. Epub 2024 May 21. Immunity. 2024. PMID: 38776918
Active maintenance of CD8+ T cell naivety through regulation of global genome architecture.
Russ BE, Barugahare A, Dakle P, Tsyganov K, Quon S, Yu B, Li J, Lee JKC, Olshansky M, He Z, Harrison PF, See M, Nussing S, Morey AE, Udupa VA, Bennett TJ, Kallies A, Murre C, Collas P, Powell D, Goldrath AW, Turner SJ. Russ BE, et al. Among authors: nussing s. Cell Rep. 2023 Oct 31;42(10):113301. doi: 10.1016/j.celrep.2023.113301. Epub 2023 Oct 19. Cell Rep. 2023. PMID: 37858463 Free PMC article.
Active maintenance of CD8+ T cell naïvety through regulation of global genome architecture.
Russ BE, Tsyganov K, Quon S, Yu B, Li J, Lee JKC, Olshansky M, He Z, Harrison PF, Barugahare A, See M, Nussing S, Morey AE, Udupa VA, Bennett TJ, Kallies A, Murre C, Collas P, Powell D, Goldrath AW, Turner SJ. Russ BE, et al. Among authors: nussing s. bioRxiv [Preprint]. 2023 Feb 27:2023.02.26.530139. doi: 10.1101/2023.02.26.530139. bioRxiv. 2023. Update in: Cell Rep. 2023 Oct 31;42(10):113301. doi: 10.1016/j.celrep.2023.113301 PMID: 36909629 Free PMC article. Updated. Preprint.
MYB orchestrates T cell exhaustion and response to checkpoint inhibition.
Tsui C, Kretschmer L, Rapelius S, Gabriel SS, Chisanga D, Knöpper K, Utzschneider DT, Nüssing S, Liao Y, Mason T, Torres SV, Wilcox SA, Kanev K, Jarosch S, Leube J, Nutt SL, Zehn D, Parish IA, Kastenmüller W, Shi W, Buchholz VR, Kallies A. Tsui C, et al. Among authors: nussing s. Nature. 2022 Sep;609(7926):354-360. doi: 10.1038/s41586-022-05105-1. Epub 2022 Aug 17. Nature. 2022. PMID: 35978192 Free PMC article.
SATB1 ensures appropriate transcriptional programs within naïve CD8+ T cells.
Nüssing S, Miosge LA, Lee K, Olshansky M, Barugahare A, Roots CM, Sontani Y, Day EB, Koutsakos M, Kedzierska K, Goodnow CC, Russ BE, Daley SR, Turner SJ. Nüssing S, et al. Immunol Cell Biol. 2022 Sep;100(8):636-652. doi: 10.1111/imcb.12566. Epub 2022 Jul 13. Immunol Cell Biol. 2022. PMID: 35713361 Free PMC article.
Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance.
Wagle MV, Vervoort SJ, Kelly MJ, Van Der Byl W, Peters TJ, Martin BP, Martelotto LG, Nüssing S, Ramsbottom KM, Torpy JR, Knight D, Reading S, Thia K, Miosge LA, Howard DR, Gloury R, Gabriel SS, Utzschneider DT, Oliaro J, Powell JD, Luciani F, Trapani JA, Johnstone RW, Kallies A, Goodnow CC, Parish IA. Wagle MV, et al. Among authors: nussing s. Nat Commun. 2021 May 13;12(1):2782. doi: 10.1038/s41467-021-23044-9. Nat Commun. 2021. PMID: 33986293 Free PMC article.
Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients.
Nguyen THO, Koutsakos M, van de Sandt CE, Crawford JC, Loh L, Sant S, Grzelak L, Allen EK, Brahm T, Clemens EB, Auladell M, Hensen L, Wang Z, Nüssing S, Jia X, Günther P, Wheatley AK, Kent SJ, Aban M, Deng YM, Laurie KL, Hurt AC, Gras S, Rossjohn J, Crowe J, Xu J, Jackson D, Brown LE, La Gruta N, Chen W, Doherty PC, Turner SJ, Kotsimbos TC, Thomas PG, Cheng AC, Kedzierska K. Nguyen THO, et al. Among authors: nussing s. Nat Commun. 2021 May 11;12(1):2691. doi: 10.1038/s41467-021-23018-x. Nat Commun. 2021. PMID: 33976217 Free PMC article.
Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin.
Hochheiser K, Wiede F, Wagner T, Freestone D, Enders MH, Olshansky M, Russ B, Nüssing S, Bawden E, Braun A, Bachem A, Gressier E, McConville R, Park SL, Jones CM, Davey GM, Gyorki DE, Tscharke D, Parish IA, Turner S, Herold MJ, Tiganis T, Bedoui S, Gebhardt T. Hochheiser K, et al. Among authors: nussing s. J Exp Med. 2021 Jun 7;218(6):e20200940. doi: 10.1084/jem.20200940. J Exp Med. 2021. PMID: 33914023 Free PMC article.
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