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Page 1
Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype.
Rademakers T, Manca M, Jin H, Orban T, Perisic LM, Frissen HJM, Rühle F, Hautvast P, van Rijssel J, van Kuijk K, Mees BME, Peutz-Kootstra CJ, Heeneman S, Daemen MJAP, Pasterkamp G, Stoll M, van Zandvoort MAMJ, Hedin U, Dequiedt F, van Buul JD, Sluimer JC, Biessen EAL. Rademakers T, et al. Among authors: biessen eal. Angiogenesis. 2024 Aug;27(3):461-474. doi: 10.1007/s10456-024-09921-z. Epub 2024 May 23. Angiogenesis. 2024. PMID: 38780883 Free PMC article.
Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability.
Jin H, Zhang C, Nagenborg J, Juhasz P, Ruder AV, Sikkink CJJM, Mees BME, Waring O, Sluimer JC, Neumann D, Goossens P, Donners MMPC, Mardinoglu A, Biessen EAL. Jin H, et al. Among authors: biessen eal. Cardiovasc Diabetol. 2024 Jul 8;23(1):240. doi: 10.1186/s12933-024-02339-3. Cardiovasc Diabetol. 2024. PMID: 38978031 Free PMC article.
Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis.
Vermeulen I, Li M, van Mourik H, Yadati T, Eijkel G, Balluff B, Godschalk R, Temmerman L, Biessen EAL, Kulkarni A, Theys J, Houben T, Cillero-Pastor B, Shiri-Sverdlov R. Vermeulen I, et al. Among authors: biessen eal. FEBS J. 2024 Dec 26. doi: 10.1111/febs.17358. Online ahead of print. FEBS J. 2024. PMID: 39726152
Colony stimulating factor 1 receptor (Csf1r) expressing cell ablation in mafia (macrophage-specific Fas-induced apoptosis) mice alters monocyte landscape and atherosclerotic lesion characteristics.
Medina I, Wieland EB, Temmerman L, Otten JJT, Bermudez B, Bot I, Rademakers T, Wijnands E, Schurgers L, Mees B, van Berkel TJC, Goossens P, Biessen EAL. Medina I, et al. Among authors: biessen eal. Eur J Immunol. 2024 Nov;54(11):e2350943. doi: 10.1002/eji.202350943. Epub 2024 Sep 4. Eur J Immunol. 2024. PMID: 39233527
The calcium-sensing-receptor (CaSR) in adipocytes contributes to sex-differences in the susceptibility to high fat diet induced obesity and atherosclerosis.
Adam S, Maas SL, Huchzermeier R, Rakateli L, Abschlag K, Hohl M, Liao L, Bartneck M, Teunissen M, Wouters K, Santovito D, Jankowski J, Biessen EAL, van der Vorst EPC. Adam S, et al. Among authors: biessen eal. EBioMedicine. 2024 Sep;107:105293. doi: 10.1016/j.ebiom.2024.105293. Epub 2024 Aug 14. EBioMedicine. 2024. PMID: 39146692 Free PMC article.
CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization.
Singh A, Kraaijeveld AO, Curaj A, Wichapong K, Hammerich L, de Jager SCA, Bot I, Atamas SP, van Berkel TJC, Jukema JW, Comerford I, McColl SR, Mees B, Heemskerk JWM, Nicolaes GAF, Hackeng T, Liehn EA, Tacke F, Biessen EAL. Singh A, et al. Among authors: biessen eal. Front Immunol. 2024 May 13;15:1327051. doi: 10.3389/fimmu.2024.1327051. eCollection 2024. Front Immunol. 2024. PMID: 38807599 Free PMC article.
Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients.
Lu C, Donners MMPC, de Baaij JBJ, Jin H, Otten JJT, Manca M, van Zonneveld AJ, Jukema JW, Kraaijeveld A, Kuiper J, Pasterkamp G, Mees B, Sluimer JC, Cavill R, Karel JMH, Goossens P, Biessen EAL. Lu C, et al. Among authors: biessen eal. Front Immunol. 2024 Feb 12;15:1286382. doi: 10.3389/fimmu.2024.1286382. eCollection 2024. Front Immunol. 2024. PMID: 38410507 Free PMC article.
In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells.
Christ A, Maas SL, Jin H, Lu C, Legein B, Wijnands E, Temmerman L, Otten J, Isaacs A, Zenke M, Stoll M, Biessen EAL, van der Vorst EPC. Christ A, et al. Among authors: biessen eal. Free Radic Biol Med. 2024 Jan;210:406-415. doi: 10.1016/j.freeradbiomed.2023.11.044. Epub 2023 Dec 5. Free Radic Biol Med. 2024. PMID: 38061606 Free article.
194 results