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Targeting enhancer reprogramming to mitigate MEK inhibitor resistance in preclinical models of advanced ovarian cancer.
Liu S, Zou Q, Chen JP, Yao X, Guan P, Liang W, Deng P, Lai X, Yin J, Chen J, Chen R, Yu Z, Xiao R, Sun Y, Hong JH, Liu H, Lu H, Chen J, Bei JX, Koh J, Chan JY, Wang B, Kang T, Yu Q, Teh BT, Liu J, Xiong Y, Tan J. Liu S, et al. Among authors: liu j, liu h. J Clin Invest. 2021 Oct 15;131(20):e145035. doi: 10.1172/JCI145035. J Clin Invest. 2021. PMID: 34464356 Free PMC article.
CREBBP cooperates with the cell cycle machinery to attenuate chidamide sensitivity in relapsed/refractory diffuse large B-cell lymphoma.
Sun Y, Gao Y, Chen J, Huang L, Deng P, Chen J, Chai KXY, Hong JH, Chan JY, He H, Wang Y, Cheah D, Lim JQ, Chia BKH, Huang D, Liu L, Liu S, Wang X, Teng Y, Pang D, Grigoropoulos NF, Teh BT, Yu Q, Lim ST, Li W, Ong CK, Huang H, Tan J. Sun Y, et al. Among authors: liu l, liu s. Cancer Lett. 2021 Sep 2;521:268-280. doi: 10.1016/j.canlet.2021.09.002. Online ahead of print. Cancer Lett. 2021. PMID: 34481935 Free article.
RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer.
Deng P, Wang Z, Chen J, Liu S, Yao X, Liu S, Liu L, Yu Z, Huang Y, Xiong Z, Xiao R, Gao J, Liang W, Chen J, Liu H, Hong JH, Chan JY, Guan P, Chen J, Wang Y, Yin J, Li J, Zheng M, Zhang C, Zhou P, Kang T, Teh BT, Yu Q, Zuo Z, Jiang Q, Liu J, Xiong Y, Xia X, Tan J. Deng P, et al. Among authors: liu j, liu h, liu l, liu s. J Clin Invest. 2022 Nov 15;132(22):e159628. doi: 10.1172/JCI159628. J Clin Invest. 2022. PMID: 36201246 Free PMC article.
Aberrant JAK-STAT signaling-mediated chromatin remodeling impairs the sensitivity of NK/T-cell lymphoma to chidamide.
Chen J, Zuo Z, Gao Y, Yao X, Guan P, Wang Y, Li Z, Liu Z, Hong JH, Deng P, Chan JY, Cheah DMZ, Lim J, Chai KXY, Chia BKH, Pang JWL, Koh J, Huang D, He H, Sun Y, Liu L, Liu S, Huang Y, Wang X, You H, Saraf SA, Grigoropoulos NF, Li X, Bei J, Kang T, Lim ST, Teh BT, Huang H, Ong CK, Tan J. Chen J, et al. Among authors: liu z, liu l, liu s. Clin Epigenetics. 2023 Feb 6;15(1):19. doi: 10.1186/s13148-023-01436-6. Clin Epigenetics. 2023. PMID: 36740715 Free PMC article. Clinical Trial.
Pharmacological modulation of RB1 activity mitigates resistance to neoadjuvant chemotherapy in locally advanced rectal cancer.
Yu Z, Deng P, Chen Y, Lin D, Liu S, Hong J, Guan P, Chen J, Zhong ME, Chen J, Chen X, Sun Y, Wang Y, Wang P, Cai Z, Chan JY, Huang Y, Xiao R, Guo Y, Zeng X, Wang W, Zou Y, Yu Q, Lan P, Teh BT, Wu X, Tan J. Yu Z, et al. Among authors: liu s. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2304619121. doi: 10.1073/pnas.2304619121. Epub 2024 Jan 30. Proc Natl Acad Sci U S A. 2024. PMID: 38289962 Free PMC article.
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