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Tezacaftor is a direct inhibitor of sphingolipid delta-4 desaturase enzyme (DEGS).
Ciobanu DZ, Liessi N, Tomati V, Capurro V, Bertozzi SM, Summa M, Bertorelli R, Loberto N, Dobi D, Aureli M, Nobbio L, Bandiera T, Pedemonte N, Bassi R, Armirotti A. Ciobanu DZ, et al. Among authors: armirotti a. J Cyst Fibros. 2024 Nov;23(6):1167-1172. doi: 10.1016/j.jcf.2024.05.004. Epub 2024 May 24. J Cyst Fibros. 2024. PMID: 38789319 Free article.
Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.
Pedemonte N, Tomati V, Sondo E, Caci E, Millo E, Armirotti A, Damonte G, Zegarra-Moran O, Galietta LJ. Pedemonte N, et al. Among authors: armirotti a. J Biol Chem. 2011 Apr 29;286(17):15215-26. doi: 10.1074/jbc.M110.184267. Epub 2011 Mar 7. J Biol Chem. 2011. PMID: 21383017 Free PMC article.
Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors.
Vitale R, Ottonello G, Petracca R, Bertozzi SM, Ponzano S, Armirotti A, Berteotti A, Dionisi M, Cavalli A, Piomelli D, Bandiera T, Bertozzi F. Vitale R, et al. Among authors: armirotti a. ChemMedChem. 2014 Feb;9(2):323-36. doi: 10.1002/cmdc.201300416. Epub 2014 Jan 8. ChemMedChem. 2014. PMID: 24403170 Free article.
Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain.
Moreno-Sanz G, Barrera B, Armirotti A, Bertozzi SM, Scarpelli R, Bandiera T, Prieto JG, Duranti A, Tarzia G, Merino G, Piomelli D. Moreno-Sanz G, et al. Among authors: armirotti a. Pharmacol Res. 2014 Sep;87:87-93. doi: 10.1016/j.phrs.2014.06.004. Epub 2014 Jun 30. Pharmacol Res. 2014. PMID: 24993496 Free PMC article.
Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse.
Justinova Z, Panlilio LV, Moreno-Sanz G, Redhi GH, Auber A, Secci ME, Mascia P, Bandiera T, Armirotti A, Bertorelli R, Chefer SI, Barnes C, Yasar S, Piomelli D, Goldberg SR. Justinova Z, et al. Among authors: armirotti a. Neuropsychopharmacology. 2015 Aug;40(9):2185-97. doi: 10.1038/npp.2015.62. Epub 2015 Mar 10. Neuropsychopharmacology. 2015. PMID: 25754762 Free PMC article.
Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.
Sasso O, Migliore M, Habrant D, Armirotti A, Albani C, Summa M, Moreno-Sanz G, Scarpelli R, Piomelli D. Sasso O, et al. Among authors: armirotti a. FASEB J. 2015 Jun;29(6):2616-27. doi: 10.1096/fj.15-270637. Epub 2015 Mar 10. FASEB J. 2015. PMID: 25757568 Free PMC article.
A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation.
Ribeiro A, Pontis S, Mengatto L, Armirotti A, Chiurchiù V, Capurro V, Fiasella A, Nuzzi A, Romeo E, Moreno-Sanz G, Maccarrone M, Reggiani A, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D. Ribeiro A, et al. Among authors: armirotti a. ACS Chem Biol. 2015 Aug 21;10(8):1838-46. doi: 10.1021/acschembio.5b00114. Epub 2015 Apr 15. ACS Chem Biol. 2015. PMID: 25874594 Free PMC article.
148 results