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Tezacaftor is a direct inhibitor of sphingolipid delta-4 desaturase enzyme (DEGS).
Ciobanu DZ, Liessi N, Tomati V, Capurro V, Bertozzi SM, Summa M, Bertorelli R, Loberto N, Dobi D, Aureli M, Nobbio L, Bandiera T, Pedemonte N, Bassi R, Armirotti A. Ciobanu DZ, et al. Among authors: bassi r. J Cyst Fibros. 2024 Nov;23(6):1167-1172. doi: 10.1016/j.jcf.2024.05.004. Epub 2024 May 24. J Cyst Fibros. 2024. PMID: 38789319 Free article.
GM1 as Adjuvant of Innovative Therapies for Cystic Fibrosis Disease.
Mancini G, Loberto N, Olioso D, Dechecchi MC, Cabrini G, Mauri L, Bassi R, Schiumarini D, Chiricozzi E, Lippi G, Pesce E, Sonnino S, Pedemonte N, Tamanini A, Aureli M. Mancini G, et al. Among authors: bassi r. Int J Mol Sci. 2020 Jun 24;21(12):4486. doi: 10.3390/ijms21124486. Int J Mol Sci. 2020. PMID: 32599772 Free PMC article.
β-Glucocerebrosidase Deficiency Activates an Aberrant Lysosome-Plasma Membrane Axis Responsible for the Onset of Neurodegeneration.
Lunghi G, Carsana EV, Loberto N, Cioccarelli L, Prioni S, Mauri L, Bassi R, Duga S, Straniero L, Asselta R, Soldà G, Di Fonzo A, Frattini E, Magni M, Liessi N, Armirotti A, Ferrari E, Samarani M, Aureli M. Lunghi G, et al. Among authors: bassi r. Cells. 2022 Jul 29;11(15):2343. doi: 10.3390/cells11152343. Cells. 2022. PMID: 35954187 Free PMC article.
The glycosphingolipid hydrolases in the central nervous system.
Aureli M, Samarani M, Loberto N, Bassi R, Murdica V, Prioni S, Prinetti A, Sonnino S. Aureli M, et al. Among authors: bassi r. Mol Neurobiol. 2014 Aug;50(1):76-87. doi: 10.1007/s12035-013-8592-6. Epub 2013 Nov 27. Mol Neurobiol. 2014. PMID: 24282076 Review.
Exploring the link between ceramide and ionizing radiation.
Aureli M, Murdica V, Loberto N, Samarani M, Prinetti A, Bassi R, Sonnino S. Aureli M, et al. Among authors: bassi r. Glycoconj J. 2014 Oct;31(6-7):449-59. doi: 10.1007/s10719-014-9541-y. Glycoconj J. 2014. PMID: 25129488 Review.
Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells.
Schiumarini D, Loberto N, Mancini G, Bassi R, Giussani P, Chiricozzi E, Samarani M, Munari S, Tamanini A, Cabrini G, Lippi G, Dechecchi MC, Sonnino S, Aureli M. Schiumarini D, et al. Among authors: bassi r. Mediators Inflamm. 2017;2017:1730245. doi: 10.1155/2017/1730245. Epub 2017 Dec 3. Mediators Inflamm. 2017. PMID: 29333001 Free PMC article.
Cross-talk between CFTR and sphingolipids in cystic fibrosis.
Dobi D, Loberto N, Bassi R, Pistocchi A, Lunghi G, Tamanini A, Aureli M. Dobi D, et al. Among authors: bassi r. FEBS Open Bio. 2023 Sep;13(9):1601-1614. doi: 10.1002/2211-5463.13660. Epub 2023 Jun 22. FEBS Open Bio. 2023. PMID: 37315117 Free PMC article. Review.
489 results