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HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer.
Ferretti GDS, Quaas CE, Bertolini I, Zuccotti A, Saatci O, Kashatus JA, Sharmin S, Lu DY, Poli ANR, Quesnelle AF, Rodriguez-Blanco J, de Cubas AA, Hobbs GA, Liu Q, O'Bryan JP, Salvino JM, Kashatus DF, Sahin O, Barnoud T. Ferretti GDS, et al. Among authors: o bryan jp. Cell Death Differ. 2024 Jul;31(7):881-896. doi: 10.1038/s41418-024-01310-9. Epub 2024 May 28. Cell Death Differ. 2024. PMID: 38802657 Free PMC article.
Intersectin - many facets of a scaffold protein.
Mintoo M, Rajagopalan V, O'Bryan JP. Mintoo M, et al. Among authors: o bryan jp. Biochem Soc Trans. 2024 Feb 28;52(1):1-13. doi: 10.1042/BST20211241. Biochem Soc Trans. 2024. PMID: 38174740 Review.
Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
Akkapeddi P, Hattori T, Khan I, Glasser E, Koide A, Ketavarapu G, Whaby M, Zuberi M, Teng KW, Lefler J, Maso L, Bang I, Ostrowski MC, O'Bryan JP, Koide S. Akkapeddi P, et al. Among authors: o bryan jp. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2302485120. doi: 10.1073/pnas.2302485120. Epub 2023 Jul 3. Proc Natl Acad Sci U S A. 2023. PMID: 37399416 Free PMC article.
Inhibition and degradation of NRAS with a pan-NRAS monobody.
Whaby M, Ketavarapu G, Koide A, Mazzei M, Mintoo M, Glasser E, Patel U, Nasarre C, Sale MJ, McCormick F, Koide S, O'Bryan JP. Whaby M, et al. Among authors: o bryan jp. Oncogene. 2024 Nov;43(48):3489-3497. doi: 10.1038/s41388-024-03186-y. Epub 2024 Oct 8. Oncogene. 2024. PMID: 39379700 Free PMC article.
Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway.
Sofi MH, Tian L, Schutt S, Khan I, Choi HJ, Wu Y, Bastian D, Ticer T, Kassir MF, Atilgan FC, Kim J, Sui X, Zivkovic A, Mehrotra S, O'Bryan JP, Stark H, Martin PJ, Ogretmen B, Yu XZ. Sofi MH, et al. Among authors: o bryan jp. Leukemia. 2022 Jul;36(7):1907-1915. doi: 10.1038/s41375-022-01581-6. Epub 2022 May 5. Leukemia. 2022. PMID: 35513703 Free PMC article.
77 results