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A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan G, Nury H, Steyaert J, Baenziger JE, Ulens C. Hénault CM, et al. Among authors: bertrand d. Nat Chem Biol. 2019 Dec;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4. Epub 2019 Oct 7. Nat Chem Biol. 2019. PMID: 31591563 Free PMC article.
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.
Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C. Spurny R, et al. Among authors: bertrand s, bertrand d. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3028-34. doi: 10.1073/pnas.1208208109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035248 Free PMC article.
Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).
Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SCR, Ulens C. Spurny R, et al. Among authors: bertrand s, bertrand d. J Biol Chem. 2013 Mar 22;288(12):8355-8364. doi: 10.1074/jbc.M112.424507. Epub 2013 Jan 30. J Biol Chem. 2013. PMID: 23364792 Free PMC article.
743 results