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A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan G, Nury H, Steyaert J, Baenziger JE, Ulens C. Hénault CM, et al. Among authors: brams m. Nat Chem Biol. 2019 Dec;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4. Epub 2019 Oct 7. Nat Chem Biol. 2019. PMID: 31591563 Free PMC article.
Structural hot spots for the solubility of globular proteins.
Ganesan A, Siekierska A, Beerten J, Brams M, Van Durme J, De Baets G, Van der Kant R, Gallardo R, Ramakers M, Langenberg T, Wilkinson H, De Smet F, Ulens C, Rousseau F, Schymkowitz J. Ganesan A, et al. Among authors: brams m. Nat Commun. 2016 Feb 24;7:10816. doi: 10.1038/ncomms10816. Nat Commun. 2016. PMID: 26905391 Free PMC article.
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.
Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C. Spurny R, et al. Among authors: brams m. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3028-34. doi: 10.1073/pnas.1208208109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035248 Free PMC article.
Family of prokaryote cyclic nucleotide-modulated ion channels.
Brams M, Kusch J, Spurny R, Benndorf K, Ulens C. Brams M, et al. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7855-60. doi: 10.1073/pnas.1401917111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821777 Free PMC article.
68 results