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A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.
Hulin-Curtis S, Geary JK, MacLachlan BJ, Altmann DM, Baillon L, Cole DK, Greenshields-Watson A, Hesketh SJ, Humphreys IR, Jones IM, Lauder SN, Mason GH, Smart K, Scourfield DO, Scott J, Sukhova K, Stanton RJ, Wall A, Rizkallah PJ, Barclay WS, Gallimore A, Godkin A. Hulin-Curtis S, et al. Among authors: humphreys ir. Cell Rep. 2024 Jun 25;43(6):114259. doi: 10.1016/j.celrep.2024.114259. Epub 2024 May 30. Cell Rep. 2024. PMID: 38819988 Free article.
A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications.
Bliss CM, Hulin-Curtis SL, Williams M, Marušková M, Davies JA, Statkute E, Baker AT, Stack L, Kerstetter L, Kerr-Jones LE, Milward KF, Russell G, George SJ, Badder LM, Stanton RJ, Coughlan L, Humphreys IR, Parker AL. Bliss CM, et al. Among authors: humphreys ir. Mol Ther Methods Clin Dev. 2024 Jul 30;32(3):101308. doi: 10.1016/j.omtm.2024.101308. eCollection 2024 Sep 12. Mol Ther Methods Clin Dev. 2024. PMID: 39206304 Free PMC article.
Protein interactions in human pathogens revealed through deep learning.
Humphreys IR, Zhang J, Baek M, Wang Y, Krishnakumar A, Pei J, Anishchenko I, Tower CA, Jackson BA, Warrier T, Hung DT, Peterson SB, Mougous JD, Cong Q, Baker D. Humphreys IR, et al. Nat Microbiol. 2024 Oct;9(10):2642-2652. doi: 10.1038/s41564-024-01791-x. Epub 2024 Sep 18. Nat Microbiol. 2024. PMID: 39294458 Free PMC article.
Computational design of serine hydrolases.
Lauko A, Pellock SJ, Anischanka I, Sumida KH, Juergens D, Ahern W, Shida A, Hunt A, Kalvet I, Norn C, Humphreys IR, Jamieson C, Kang A, Brackenbrough E, Bera AK, Sankaran B, Houk KN, Baker D. Lauko A, et al. Among authors: humphreys ir. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.610411. doi: 10.1101/2024.08.29.610411. bioRxiv. 2024. PMID: 39257749 Free PMC article. Preprint.
Essential and virulence-related protein interactions of pathogens revealed through deep learning.
Humphreys IR, Zhang J, Baek M, Wang Y, Krishnakumar A, Pei J, Anishchenko I, Tower CA, Jackson BA, Warrier T, Hung DT, Peterson SB, Mougous JD, Cong Q, Baker D. Humphreys IR, et al. bioRxiv [Preprint]. 2024 Apr 12:2024.04.12.589144. doi: 10.1101/2024.04.12.589144. bioRxiv. 2024. Update in: Nat Microbiol. 2024 Oct;9(10):2642-2652. doi: 10.1038/s41564-024-01791-x PMID: 38645026 Free PMC article. Updated. Preprint.
Generalized biomolecular modeling and design with RoseTTAFold All-Atom.
Krishna R, Wang J, Ahern W, Sturmfels P, Venkatesh P, Kalvet I, Lee GR, Morey-Burrows FS, Anishchenko I, Humphreys IR, McHugh R, Vafeados D, Li X, Sutherland GA, Hitchcock A, Hunter CN, Kang A, Brackenbrough E, Bera AK, Baek M, DiMaio F, Baker D. Krishna R, et al. Among authors: humphreys ir. Science. 2024 Apr 19;384(6693):eadl2528. doi: 10.1126/science.adl2528. Epub 2024 Apr 19. Science. 2024. PMID: 38452047 Free article.
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion.
Whiteside SK, Grant FM, Alvisi G, Clarke J, Tang L, Imianowski CJ, Zhang B, Evans AC, Wesolowski AJ, Conti AG, Yang J, Lauder SN, Clement M, Humphreys IR, Dooley J, Burton O, Liston A, Alloisio M, Voulaz E, Langhorne J, Okkenhaug K, Lugli E, Roychoudhuri R. Whiteside SK, et al. Among authors: humphreys ir. Sci Immunol. 2023 Dec 15;8(90):eabo5558. doi: 10.1126/sciimmunol.abo5558. Epub 2023 Dec 15. Sci Immunol. 2023. PMID: 38100544 Free PMC article.
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle.
Wang Y, Gallagher LA, Andrade PA, Liu A, Humphreys IR, Turkarslan S, Cutler KJ, Arrieta-Ortiz ML, Li Y, Radey MC, McLean JS, Cong Q, Baker D, Baliga NS, Peterson SB, Mougous JD. Wang Y, et al. Among authors: humphreys ir. Cell. 2023 Oct 26;186(22):4803-4817.e13. doi: 10.1016/j.cell.2023.08.017. Epub 2023 Sep 7. Cell. 2023. PMID: 37683634 Free PMC article.
82 results