Zhang D - Search Results

1

Mass Balance, Metabolic Pathways, Absolute Bioavailability, and Pharmacokinetics of Giredestrant in Healthy Subjects.

Kshirsagar S, Chen YC, Yu J, Gates MR, Kawakatsu S, Khojasteh SC, Ma S, Musib L, Malhi V, Osaghae U, Wang J, Cho S, Tang YT, Zhang D, Zhao W, De Bruyn T. Kshirsagar S, et al. Among authors: zhang d. Drug Metab Dispos. 2024 Jul 16;52(8):847-857. doi: 10.1124/dmd.124.001688. Drug Metab Dispos. 2024. PMID: 38834357

2

Amide N-glucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans.

Zhang D, Zhao W, Roongta VA, Mitroka JG, Klunk LJ, Zhu M. Zhang D, et al. Drug Metab Dispos. 2004 May;32(5):545-51. doi: 10.1124/dmd.32.5.545. Drug Metab Dispos. 2004. PMID: 15100177

3

Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes.

Zhu M, Zhao W, Jimenez H, Zhang D, Yeola S, Dai R, Vachharajani N, Mitroka J. Zhu M, et al. Among authors: zhang d. Drug Metab Dispos. 2005 Apr;33(4):500-7. doi: 10.1124/dmd.104.000836. Epub 2005 Jan 7. Drug Metab Dispos. 2005. PMID: 15640381

4

Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data.

Zhu M, Ma L, Zhang D, Ray K, Zhao W, Humphreys WG, Skiles G, Sanders M, Zhang H. Zhu M, et al. Among authors: zhang d, zhang h. Drug Metab Dispos. 2006 Oct;34(10):1722-33. doi: 10.1124/dmd.106.009241. Epub 2006 Jun 30. Drug Metab Dispos. 2006. PMID: 16815965

5

Rapid and sensitive characterization of the metabolite formation enzyme kinetics of radiolabeled drugs using stop-flow liquid radiochromatography.

Zhao W, Wang L, Zhang D, Zhu M. Zhao W, et al. Among authors: zhang d. Drug Metab Lett. 2008 Jan;2(1):41-6. doi: 10.2174/187231208783478470. Drug Metab Lett. 2008. PMID: 19356069

6

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.

Fan PW, Zhang D, Halladay JS, Driscoll JP, Khojasteh SC. Fan PW, et al. Among authors: zhang d. Drug Metab Dispos. 2016 Aug;44(8):1253-61. doi: 10.1124/dmd.116.070169. Epub 2016 Apr 26. Drug Metab Dispos. 2016. PMID: 27117704 Review.

7

Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates.

Zhang D, Yu SF, Ma Y, Xu K, Dragovich PS, Pillow TH, Liu L, Del Rosario G, He J, Pei Z, Sadowsky JD, Erickson HK, Hop CE, Khojasteh SC. Zhang D, et al. Drug Metab Dispos. 2016 Sep;44(9):1517-23. doi: 10.1124/dmd.116.070631. Epub 2016 Jul 14. Drug Metab Dispos. 2016. PMID: 27417182 Free PMC article.

8

Non-cytochrome P450-mediated bioactivation and its toxicological relevance.

Gan J, Ma S, Zhang D. Gan J, et al. Among authors: zhang d. Drug Metab Rev. 2016 Nov;48(4):473-501. doi: 10.1080/03602532.2016.1225756. Epub 2016 Sep 20. Drug Metab Rev. 2016. PMID: 27533622 Review.

9

Antibody Drug Conjugates Differentiate Uptake and DNA Alkylation of Pyrrolobenzodiazepines in Tumors from Organs of Xenograft Mice.

Ma Y, Khojasteh SC, Hop CE, Erickson HK, Polson A, Pillow TH, Yu SF, Wang H, Dragovich PS, Zhang D. Ma Y, et al. Among authors: zhang d. Drug Metab Dispos. 2016 Dec;44(12):1958-1962. doi: 10.1124/dmd.116.073031. Epub 2016 Sep 28. Drug Metab Dispos. 2016. PMID: 27683653

10

Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.

Zhang D, Pillow TH, Ma Y, Cruz-Chuh JD, Kozak KR, Sadowsky JD, Lewis Phillips GD, Guo J, Darwish M, Fan P, Chen J, He C, Wang T, Yao H, Xu Z, Chen J, Wai J, Pei Z, Hop CE, Khojasteh SC, Dragovich PS. Zhang D, et al. ACS Med Chem Lett. 2016 Aug 26;7(11):988-993. doi: 10.1021/acsmedchemlett.6b00233. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882196 Free PMC article.

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