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Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling.
Domingues N, Calcagni' A, Pires J, Freire SR, Herz NJ, Huynh T, Wieciorek K, Moreno MJ, Outeiro TF, Girão H, Milosevic I, Ballabio A, Raimundo N. Domingues N, et al. Among authors: milosevic i. bioRxiv [Preprint]. 2024 Jun 2:2024.05.31.596474. doi: 10.1101/2024.05.31.596474. bioRxiv. 2024. PMID: 38853929 Free PMC article. Preprint.
Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain.
Agostini F, Pereyra L, Dale J, Yambire KF, Maglioni S, Schiavi A, Ventura N, Milosevic I, Raimundo N. Agostini F, et al. Among authors: milosevic i. bioRxiv [Preprint]. 2024 Mar 7:2024.03.06.583589. doi: 10.1101/2024.03.06.583589. bioRxiv. 2024. Update in: J Biol Chem. 2024 Jul;300(7):107403. doi: 10.1016/j.jbc.2024.107403 PMID: 38496624 Free PMC article. Updated. Preprint.
Mitochondrial fission requires DRP1 but not dynamins.
Fonseca TB, Sánchez-Guerrero Á, Milosevic I, Raimundo N. Fonseca TB, et al. Among authors: milosevic i. Nature. 2019 Jun;570(7761):E34-E42. doi: 10.1038/s41586-019-1296-y. Epub 2019 Jun 19. Nature. 2019. PMID: 31217603 No abstract available.
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N. Yambire KF, et al. Among authors: milosevic i. Elife. 2019 Dec 3;8:e51031. doi: 10.7554/eLife.51031. Elife. 2019. PMID: 31793879 Free PMC article.
Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.
Fernandez-Mosquera L, Yambire KF, Couto R, Pereyra L, Pabis K, Ponsford AH, Diogo CV, Stagi M, Milosevic I, Raimundo N. Fernandez-Mosquera L, et al. Among authors: milosevic i. Autophagy. 2019 Sep;15(9):1572-1591. doi: 10.1080/15548627.2019.1586256. Epub 2019 Mar 27. Autophagy. 2019. PMID: 30917721 Free PMC article.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R… See abstract for full author list ➔ Klionsky DJ, et al. Among authors: milosevic i. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Autophagy. 2021. PMID: 33634751 Free PMC article.
208 results