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Single nucleotide variation catalog from clinical isolates mapped on tertiary and quaternary structures of ESX-1-related proteins reveals critical regions as putative Mtb therapeutic targets.
Tzfadia O, Gijsbers A, Vujkovic A, Snobre J, Vargas R, Dewaele K, Meehan CJ, Farhat M, Hakke S, Peters PJ, de Jong BC, Siroy A, Ravelli RBG. Tzfadia O, et al. Microbiol Spectr. 2024 Aug 6;12(8):e0381623. doi: 10.1128/spectrum.03816-23. Epub 2024 Jun 14. Microbiol Spectr. 2024. PMID: 38874407 Free PMC article.
Multidrug-resistant tuberculosis control in Rwanda overcomes a successful clone that causes most disease over a quarter century.
Ngabonziza JCS, Rigouts L, Torrea G, Decroo T, Kamanzi E, Lempens P, Rucogoza A, Habimana YM, Laenen L, Niyigena BE, Uwizeye C, Ushizimpumu B, Mulders W, Ivan E, Tzfadia O, Muvunyi CM, Migambi P, Andre E, Mazarati JB, Affolabi D, Umubyeyi AN, Nsanzimana S, Portaels F, Gasana M, de Jong BC, Meehan CJ. Ngabonziza JCS, et al. Among authors: tzfadia o. J Clin Tuberc Other Mycobact Dis. 2022 Jan 24;27:100299. doi: 10.1016/j.jctube.2022.100299. eCollection 2022 May. J Clin Tuberc Other Mycobact Dis. 2022. PMID: 35146133 Free PMC article. Review.
A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region.
Ngabonziza JCS, Loiseau C, Marceau M, Jouet A, Menardo F, Tzfadia O, Antoine R, Niyigena EB, Mulders W, Fissette K, Diels M, Gaudin C, Duthoy S, Ssengooba W, André E, Kaswa MK, Habimana YM, Brites D, Affolabi D, Mazarati JB, de Jong BC, Rigouts L, Gagneux S, Meehan CJ, Supply P. Ngabonziza JCS, et al. Among authors: tzfadia o. Nat Commun. 2020 Jun 9;11(1):2917. doi: 10.1038/s41467-020-16626-6. Nat Commun. 2020. PMID: 32518235 Free PMC article.
Frameshift mutations in the mmpR5 gene can have a bedaquiline-susceptible phenotype by retaining a protein structure and function similar to wild-type Mycobacterium tuberculosis.
Snobre J, Meehan CJ, Mulders W, Rigouts L, Buyl R, de Jong BC, Van Rie A, Tzfadia O. Snobre J, et al. Among authors: tzfadia o. Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0085424. doi: 10.1128/aac.00854-24. Epub 2024 Oct 24. Antimicrob Agents Chemother. 2024. PMID: 39445816 Free PMC article.
Volatile organic compound detection of Buruli ulcer disease: Headspace analysis of Mycobacterium ulcerans and used gauzes of Buruli-compatible ulcers.
Chudy SFJ, Phanzu DM, Kolk AHJ, Sopoh GE, Barogui YT, Tzfadia O, Eddyani M, Fissette K, de Jong BC, Brinkman P. Chudy SFJ, et al. Among authors: tzfadia o. PLoS Negl Trop Dis. 2024 Sep 23;18(9):e0012514. doi: 10.1371/journal.pntd.0012514. eCollection 2024 Sep. PLoS Negl Trop Dis. 2024. PMID: 39312571 Free PMC article.
32 results