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Discovery of a potent, orally available furopyridine derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor.
Hagihara S, Ishizawa K, Kikuchi M, Kawano Y, Nishidate A, Matsumoto F, Hashimoto N, Sasaki C, Miyaguchi I, Okada O, Akashi T, Nakayama S, Ogasawara Y, Endo J. Hagihara S, et al. Among authors: akashi t. Bioorg Med Chem Lett. 2024 Sep 1;109:129848. doi: 10.1016/j.bmcl.2024.129848. Epub 2024 Jun 12. Bioorg Med Chem Lett. 2024. PMID: 38876176
Discovery of a potent orally available pyrazolopyridone derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor.
Hagihara S, Ishizawa K, Soga K, Honjo T, Takai S, Kawano Y, Kikuchi M, Nishidate A, Matsumoto F, Murase M, Hashimoto N, Sasaki C, Miyaguchi I, Okada O, Akashi T, Nakayama S, Ogasawara Y, Endo J. Hagihara S, et al. Among authors: akashi t. Bioorg Med Chem Lett. 2024 Sep 1;109:129849. doi: 10.1016/j.bmcl.2024.129849. Epub 2024 Jun 12. Bioorg Med Chem Lett. 2024. PMID: 38876177
Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Hiraizumi M, Akashi T, Murasaki K, Kishida H, Kumanomidou T, Torimoto N, Nureki O, Miyaguchi I. Hiraizumi M, et al. Among authors: akashi t. Nat Struct Mol Biol. 2024 Jan;31(1):159-169. doi: 10.1038/s41594-023-01134-0. Epub 2023 Dec 6. Nat Struct Mol Biol. 2024. PMID: 38057552 Free PMC article.
534 results