Leung I - Search Results

1

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy.

Yadav R, Schubbert S, Holder PG, Chiang EY, Kiabi N, Bogaert L, Leung I, Rashid R, Avery KN, Bonzon C, Desjarlais JR, Sanjabi S, Sharma A, Lepherd M, Shelton A, Chan P, Liu Y, Joslyn L, Hosseini I, Stefanich EG, Kamath AV, Bernett MJ, Shivva V. Yadav R, et al. Among authors: leung i. Front Pharmacol. 2024 Jun 3;15:1380000. doi: 10.3389/fphar.2024.1380000. eCollection 2024. Front Pharmacol. 2024. PMID: 38887559 Free PMC article.

2

Complex PK-PD of an engineered IL-15/IL-15Rα-Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics.

Lu D, Yadav R, Holder P, Chiang E, Sanjabi S, Poon V, Bernett M, Varma R, Liu K, Leung I, Bogaert L, Desjarlais J, Shivva V, Hosseini I, Ramanujan S. Lu D, et al. Among authors: leung i. Eur J Pharm Sci. 2023 Jul 1;186:106450. doi: 10.1016/j.ejps.2023.106450. Epub 2023 Apr 20. Eur J Pharm Sci. 2023. PMID: 37084985 Free article.

3

Engineering fully human monoclonal antibodies from murine variable regions.

Bernett MJ, Karki S, Moore GL, Leung IW, Chen H, Pong E, Nguyen DH, Jacinto J, Zalevsky J, Muchhal US, Desjarlais JR, Lazar GA. Bernett MJ, et al. J Mol Biol. 2010 Mar 12;396(5):1474-90. doi: 10.1016/j.jmb.2009.12.046. Epub 2010 Jan 4. J Mol Biol. 2010. PMID: 20045416

4

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody.

Chu SY, Horton HM, Pong E, Leung IW, Chen H, Nguyen DH, Bautista C, Muchhal US, Bernett MJ, Moore GL, Szymkowski DE, Desjarlais JR. Chu SY, et al. J Allergy Clin Immunol. 2012 Apr;129(4):1102-15. doi: 10.1016/j.jaci.2011.11.029. Epub 2012 Jan 16. J Allergy Clin Immunol. 2012. PMID: 22257644

5

Immune suppression in cynomolgus monkeys by XPro9523: an improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn.

Bernett MJ, Chu SY, Leung I, Moore GL, Lee SH, Pong E, Chen H, Phung S, Muchhal US, Horton HM, Lazar GA, Desjarlais JR, Szymkowski DE. Bernett MJ, et al. Among authors: leung i. MAbs. 2013 May-Jun;5(3):384-96. doi: 10.4161/mabs.23976. Epub 2013 Apr 2. MAbs. 2013. PMID: 23549103 Free PMC article.

6

The impact of Fc engineering on an anti-CD19 antibody: increased Fcgamma receptor affinity enhances B-cell clearing in nonhuman primates.

Zalevsky J, Leung IW, Karki S, Chu SY, Zhukovsky EA, Desjarlais JR, Carmichael DF, Lawrence CE. Zalevsky J, et al. Blood. 2009 Apr 16;113(16):3735-43. doi: 10.1182/blood-2008-10-182048. Epub 2008 Dec 24. Blood. 2009. PMID: 19109559 Free article.

7

Enhanced antibody half-life improves in vivo activity.

Zalevsky J, Chamberlain AK, Horton HM, Karki S, Leung IW, Sproule TJ, Lazar GA, Roopenian DC, Desjarlais JR. Zalevsky J, et al. Nat Biotechnol. 2010 Feb;28(2):157-9. doi: 10.1038/nbt.1601. Epub 2010 Jan 17. Nat Biotechnol. 2010. PMID: 20081867 Free PMC article.

8

Suppression of rheumatoid arthritis B cells by XmAb5871, an anti-CD19 antibody that coengages B cell antigen receptor complex and Fcγ receptor IIb inhibitory receptor.

Chu SY, Yeter K, Kotha R, Pong E, Miranda Y, Phung S, Chen H, Lee SH, Leung I, Bonzon C, Desjarlais JR, Stohl W, Szymkowski DE. Chu SY, et al. Among authors: leung i. Arthritis Rheumatol. 2014 May;66(5):1153-64. doi: 10.1002/art.38334. Arthritis Rheumatol. 2014. PMID: 24782179

9

Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus.

Horton HM, Chu SY, Ortiz EC, Pong E, Cemerski S, Leung IW, Jacob N, Zalevsky J, Desjarlais JR, Stohl W, Szymkowski DE. Horton HM, et al. J Immunol. 2011 Apr 1;186(7):4223-33. doi: 10.4049/jimmunol.1003412. Epub 2011 Feb 28. J Immunol. 2011. PMID: 21357255

10

Assessing sleep metrics in stroke survivors: a comparison between objective and subjective measures.

Lo TLT, Leung ICH, Leung LLW, Chan PPY, Ho RTH. Lo TLT, et al. Among authors: leung ich. Sleep Breath. 2024 Dec 4;29(1):45. doi: 10.1007/s11325-024-03212-z. Sleep Breath. 2024. PMID: 39630297 Free PMC article.

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