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Long term rescue of Alzheimer's deficits in vivo by one-time gene-editing of App C-terminus.
Aulston BD, Gimse K, Bazick HO, Kramar EA, Pizzo DP, Parra-Rivas LA, Sun J, Branes-Guerrero K, Checka N, Bagheri N, Satyadev N, Carlson-Stevermer J, Saito T, Saido TC, Audhya A, Wood MA, Zylka MJ, Saha K, Roy S. Aulston BD, et al. Among authors: parra rivas la. bioRxiv [Preprint]. 2024 Jun 9:2024.06.08.598099. doi: 10.1101/2024.06.08.598099. bioRxiv. 2024. PMID: 38895278 Free PMC article. Preprint.
Synapsin E-domain is essential for α-synuclein function.
Stavsky A, Parra-Rivas LA, Tal S, Riba J, Madhivanan K, Roy S, Gitler D. Stavsky A, et al. Among authors: parra rivas la. Elife. 2024 May 7;12:RP89687. doi: 10.7554/eLife.89687. Elife. 2024. PMID: 38713200 Free PMC article.
Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function.
Parra-Rivas LA, Madhivanan K, Aulston BD, Wang L, Prakashchand DD, Boyer NP, Saia-Cereda VM, Branes-Guerrero K, Pizzo DP, Bagchi P, Sundar VS, Tang Y, Das U, Scott DA, Rangamani P, Ogawa Y, Subhojit Roy. Parra-Rivas LA, et al. Neuron. 2023 Dec 20;111(24):4006-4023.e10. doi: 10.1016/j.neuron.2023.11.020. Neuron. 2023. PMID: 38128479 Free PMC article.