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Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity.
Saville KM, Al-Rahahleh RQ, Siddiqui AH, Andrews ME, Roos WP, Koczor CA, Andrews JF, Hayat F, Migaud ME, Sobol RW. Saville KM, et al. Among authors: roos wp. DNA Repair (Amst). 2024 Aug;140:103700. doi: 10.1016/j.dnarep.2024.103700. Epub 2024 Jun 4. DNA Repair (Amst). 2024. PMID: 38897003 Free article.
The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil.
Kiweler N, Schwarz H, Nguyen A, Matschos S, Mullins C, Piée-Staffa A, Brachetti C, Roos WP, Schneider G, Linnebacher M, Brenner W, Krämer OH. Kiweler N, et al. Among authors: roos wp. Cell Biol Toxicol. 2023 Oct;39(5):2401-2419. doi: 10.1007/s10565-022-09731-3. Epub 2022 May 24. Cell Biol Toxicol. 2023. PMID: 35608750 Free PMC article.
55 results