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Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions.
Pierre CN, Adams LE, Higgins JS, Anasti K, Goodman D, Mielke D, Stanfield-Oakley S, Powers JM, Li D, Rountree W, Wang Y, Edwards RJ, Alam SM, Ferrari G, Tomaras GD, Haynes BF, Baric RS, Saunders KO. Pierre CN, et al. Among authors: mielke d. PLoS Pathog. 2024 Jun 20;20(6):e1011569. doi: 10.1371/journal.ppat.1011569. eCollection 2024 Jun. PLoS Pathog. 2024. PMID: 38900807 Free PMC article.
Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.
Easterhoff D, Pollara J, Luo K, Tolbert WD, Young B, Mielke D, Jha S, O'Connell RJ, Vasan S, Kim J, Michael NL, Excler JL, Robb ML, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Nitayaphan S, Sinangil F, Tartaglia J, Phogat S, Kepler TB, Alam SM, Wiehe K, Saunders KO, Montefiori DC, Tomaras GD, Moody MA, Pazgier M, Haynes BF, Ferrari G. Easterhoff D, et al. Among authors: mielke d. J Virol. 2020 Jan 31;94(4):e01120-19. doi: 10.1128/JVI.01120-19. Print 2020 Jan 31. J Virol. 2020. PMID: 31776278 Free PMC article. Clinical Trial.
Antibody-Dependent Cellular Cytotoxicity (ADCC)-Mediating Antibodies Constrain Neutralizing Antibody Escape Pathway.
Mielke D, Bandawe G, Pollara J, Abrahams MR, Nyanhete T, Moore PL, Thebus R, Yates NL, Kappes JC, Ochsenbauer C, Garrett N, Abdool Karim S, Tomaras GD, Montefiori D, Morris L, Ferrari G, Williamson C. Mielke D, et al. Front Immunol. 2019 Dec 11;10:2875. doi: 10.3389/fimmu.2019.02875. eCollection 2019. Front Immunol. 2019. PMID: 31921139 Free PMC article.
A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.
Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. Pino M, et al. Among authors: mielke d. Sci Immunol. 2021 Jul 15;6(61):eabh3634. doi: 10.1126/sciimmunol.abh3634. Sci Immunol. 2021. PMID: 34266981 Free PMC article.
Selection of HIV Envelope Strains for Standardized Assessments of Vaccine-Elicited Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies.
Mielke D, Stanfield-Oakley S, Borate B, Fisher LH, Faircloth K, Tuyishime M, Greene K, Gao H, Williamson C, Morris L, Ochsenbauer C, Tomaras G, Haynes BF, Montefiori D, Pollara J, deCamp AC, Ferrari G. Mielke D, et al. J Virol. 2022 Jan 26;96(2):e0164321. doi: 10.1128/JVI.01643-21. Epub 2021 Nov 3. J Virol. 2022. PMID: 34730393 Free PMC article.
ADCC-mediating non-neutralizing antibodies can exert immune pressure in early HIV-1 infection.
Mielke D, Bandawe G, Zheng J, Jones J, Abrahams MR, Bekker V, Ochsenbauer C, Garrett N, Abdool Karim S, Moore PL, Morris L, Montefiori D, Anthony C, Ferrari G, Williamson C. Mielke D, et al. PLoS Pathog. 2021 Nov 17;17(11):e1010046. doi: 10.1371/journal.ppat.1010046. eCollection 2021 Nov. PLoS Pathog. 2021. PMID: 34788337 Free PMC article.
Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine.
Li D, Martinez DR, Schäfer A, Chen H, Barr M, Sutherland LL, Lee E, Parks R, Mielke D, Edwards W, Newman A, Bock KW, Minai M, Nagata BM, Gagne M, Douek DC, DeMarco CT, Denny TN, Oguin TH 3rd, Brown A, Rountree W, Wang Y, Mansouri K, Edwards RJ, Ferrari G, Sempowski GD, Eaton A, Tang J, Cain DW, Santra S, Pardi N, Weissman D, Tomai MA, Fox CB, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Baric RS, Montefiori DC, Saunders KO, Haynes BF. Li D, et al. Among authors: mielke d. bioRxiv [Preprint]. 2022 Feb 14:2022.01.26.477915. doi: 10.1101/2022.01.26.477915. bioRxiv. 2022. Update in: Nat Commun. 2022 Oct 23;13(1):6309. doi: 10.1038/s41467-022-33985-4. PMID: 35118474 Free PMC article. Updated. Preprint.
Development of flow cytometry-based assays to assess the ability of antibodies to bind to SARS-CoV-2-infected and spike-transfected cells and mediate NK cell degranulation.
Mielke D, Stanfield-Oakley S, Jha S, Keyes T, Zalaquett A, Dunn B, Rodgers N, Oguin T, Sempowski GD, Binder RA, Gray GC, Karuna S, Corey L, Hural J, Tomaras GD, Pollara J, Ferrari G. Mielke D, et al. Cytometry A. 2022 Jun;101(6):483-496. doi: 10.1002/cyto.a.24552. Epub 2022 Apr 1. Cytometry A. 2022. PMID: 35301794 Free PMC article.
Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.
Li D, Martinez DR, Schäfer A, Chen H, Barr M, Sutherland LL, Lee E, Parks R, Mielke D, Edwards W, Newman A, Bock KW, Minai M, Nagata BM, Gagne M, Douek DC, DeMarco CT, Denny TN, Oguin TH 3rd, Brown A, Rountree W, Wang Y, Mansouri K, Edwards RJ, Ferrari G, Sempowski GD, Eaton A, Tang J, Cain DW, Santra S, Pardi N, Weissman D, Tomai MA, Fox CB, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Baric RS, Montefiori DC, Saunders KO, Haynes BF. Li D, et al. Among authors: mielke d. Nat Commun. 2022 Oct 23;13(1):6309. doi: 10.1038/s41467-022-33985-4. Nat Commun. 2022. PMID: 36274085 Free PMC article.
178 results