Jursa T - Search Results

1

PHD2 enzyme is an intracellular manganese sensor that initiates the homeostatic response against elevated manganese.

Gurol KC, Jursa T, Cho EJ, Fast W, Dalby KN, Smith DR, Mukhopadhyay S. Gurol KC, et al. Among authors: jursa t. Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2402538121. doi: 10.1073/pnas.2402538121. Epub 2024 Jun 21. Proc Natl Acad Sci U S A. 2024. PMID: 38905240 Free PMC article.

2

Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity.

Liu C, Jursa T, Aschner M, Smith DR, Mukhopadhyay S. Liu C, et al. Among authors: jursa t. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2107673118. doi: 10.1073/pnas.2107673118. Proc Natl Acad Sci U S A. 2021. PMID: 34446561 Free PMC article.

3

Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure.

Hutchens S, Jursa TP, Melkote A, Grant SM, Smith DR, Mukhopadhyay S. Hutchens S, et al. Among authors: jursa tp. Am J Physiol Gastrointest Liver Physiol. 2023 Sep 1;325(3):G251-G264. doi: 10.1152/ajpgi.00047.2023. Epub 2023 Jul 18. Am J Physiol Gastrointest Liver Physiol. 2023. PMID: 37461848 Free PMC article.

4

Ceruloplasmin alters the tissue disposition and neurotoxicity of manganese, but not its loading onto transferrin.

Jursa T, Smith DR. Jursa T, et al. Toxicol Sci. 2009 Jan;107(1):182-93. doi: 10.1093/toxsci/kfn231. Epub 2008 Nov 12. Toxicol Sci. 2009. PMID: 19005224 Free PMC article.

5

Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice.

Hutchens S, Liu C, Jursa T, Shawlot W, Chaffee BK, Yin W, Gore AC, Aschner M, Smith DR, Mukhopadhyay S. Hutchens S, et al. Among authors: jursa t. J Biol Chem. 2017 Jun 9;292(23):9760-9773. doi: 10.1074/jbc.M117.783605. Epub 2017 May 1. J Biol Chem. 2017. PMID: 28461334 Free PMC article.

6

Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.

Liu C, Hutchens S, Jursa T, Shawlot W, Polishchuk EV, Polishchuk RS, Dray BK, Gore AC, Aschner M, Smith DR, Mukhopadhyay S. Liu C, et al. Among authors: jursa t. J Biol Chem. 2017 Oct 6;292(40):16605-16615. doi: 10.1074/jbc.M117.804989. Epub 2017 Aug 31. J Biol Chem. 2017. PMID: 28860195 Free PMC article.

7

SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity.

Taylor CA, Hutchens S, Liu C, Jursa T, Shawlot W, Aschner M, Smith DR, Mukhopadhyay S. Taylor CA, et al. Among authors: jursa t. J Biol Chem. 2019 Feb 8;294(6):1860-1876. doi: 10.1074/jbc.RA118.005628. Epub 2018 Dec 17. J Biol Chem. 2019. PMID: 30559290 Free PMC article.

8

SLC30A10 manganese transporter in the brain protects against deficits in motor function and dopaminergic neurotransmission under physiological conditions.

Taylor CA, Grant SM, Jursa T, Melkote A, Fulthorpe R, Aschner M, Smith DR, Gonzales RA, Mukhopadhyay S. Taylor CA, et al. Among authors: jursa t. Metallomics. 2023 Apr 3;15(4):mfad021. doi: 10.1093/mtomcs/mfad021. Metallomics. 2023. PMID: 36990693 Free PMC article.

9

Elevated thyroid manganese reduces thyroid iodine to induce hypothyroidism in mice, but not rats, lacking SLC30A10 transporter.

Hutchens S, Melkote A, Jursa T, Shawlot W, Trasande L, Smith DR, Mukhopadhyay S. Hutchens S, et al. Among authors: jursa t. Metallomics. 2024 Jul 1;16(7):mfae029. doi: 10.1093/mtomcs/mfae029. Metallomics. 2024. PMID: 38866719

10

Hair as a biomarker of environmental manganese exposure.

Eastman RR, Jursa TP, Benedetti C, Lucchini RG, Smith DR. Eastman RR, et al. Environ Sci Technol. 2013 Feb 5;47(3):1629-37. doi: 10.1021/es3035297. Epub 2013 Jan 17. Environ Sci Technol. 2013. PMID: 23259818 Free PMC article.

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