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Page 1
ATM phosphorylates the FATC domain of DNA-PK cs at threonine 4102 to promote non-homologous end joining.
Lu H, Zhang Q, Laverty DJ, Puncheon AC, Williams GJ, Nagel ZD, Chen BP, Davis AJ. Lu H, et al. Among authors: laverty dj. bioRxiv [Preprint]. 2023 Feb 2:2023.02.02.526879. doi: 10.1101/2023.02.02.526879. bioRxiv. 2023. Update in: Nucleic Acids Res. 2023 Jul 21;51(13):6770-6783. doi: 10.1093/nar/gkad505 PMID: 36778257 Free PMC article. Updated. Preprint.
CDK-independent role of D-type cyclins in regulating DNA mismatch repair.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M. Rona G, et al. Among authors: laverty dj. Mol Cell. 2024 Apr 4;84(7):1224-1242.e13. doi: 10.1016/j.molcel.2024.02.010. Epub 2024 Mar 7. Mol Cell. 2024. PMID: 38458201 Free article.
D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M. Rona G, et al. Among authors: laverty dj. bioRxiv [Preprint]. 2024 Jan 13:2024.01.12.575420. doi: 10.1101/2024.01.12.575420. bioRxiv. 2024. Update in: Mol Cell. 2024 Apr 4;84(7):1224-1242.e13. doi: 10.1016/j.molcel.2024.02.010 PMID: 38260436 Free PMC article. Updated. Preprint.
DNA-PK inhibition shows differential radiosensitization in orthotopic GBM PDX models based on DDR pathway deficits.
Dragojevic S, Smith EJ, Regan MS, Stopka SA, Baquer G, Xue Z, Zhang W, Connors MA, Kloeber JA, Hu Z, Bakken KK, Ott LL, Carlson BL, Burgenske DM, Decker PA, Tian S, Gupta SK, Laverty DJ, Eckel-Passow JE, Elmquist WF, Agar NYR, Nagel ZD, Sarkaria JN, Callaghan CM. Dragojevic S, et al. Among authors: laverty dj. Mol Cancer Ther. 2024 Oct 23. doi: 10.1158/1535-7163.MCT-24-0003. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39440433
Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization.
Chen J, Laverty DJ, Talele S, Bale A, Carlson BL, Porath KA, Bakken KK, Burgenske DM, Decker PA, Vaubel RA, Eckel-Passow JE, Bhargava R, Lou Z, Hamerlik P, Harley B, Elmquist WF, Nagel ZD, Gupta SK, Sarkaria JN. Chen J, et al. Among authors: laverty dj. Sci Transl Med. 2024 Feb 14;16(734):eadj5962. doi: 10.1126/scitranslmed.adj5962. Epub 2024 Feb 14. Sci Transl Med. 2024. PMID: 38354228
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