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Transient Adaptation of Toxoplasma gondii to Exposure by Thiosemicarbazone Drugs That Target Ribosomal Proteins Is Associated with the Upregulated Expression of Tachyzoite Transmembrane Proteins and Transporters.
Semeraro M, Boubaker G, Scaccaglia M, Müller J, Vigneswaran A, Hänggeli KPA, Amdouni Y, Kramer LH, Vismarra A, Genchi M, Pelosi G, Bisceglie F, Heller M, Uldry AC, Braga-Lagache S, Hemphill A. Semeraro M, et al. Among authors: hanggeli kpa. Int J Mol Sci. 2024 Aug 21;25(16):9067. doi: 10.3390/ijms25169067. Int J Mol Sci. 2024. PMID: 39201756 Free PMC article.
TaqMan-quantitative PCR assays applied in Neospora caninum knock-outs generated through CRISPR-Cas9 allow to determine the copy numbers of integrated dihydrofolate reductase-thymidylate synthase drug selectable markers.
Rico-San Román L, Hänggeli KPA, Hemphill A, Horcajo P, Collantes-Fernández E, Ortega-Mora LM, Boubaker G. Rico-San Román L, et al. Among authors: hanggeli kpa. Front Cell Infect Microbiol. 2024 Jun 21;14:1419209. doi: 10.3389/fcimb.2024.1419209. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38975328 Free PMC article.
Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice.
de Sousa MCF, Imhof D, Hänggeli KPA, Choi R, Hulverson MA, Arnold SLM, Van Voorhis WC, Fan E, Roberto SS, Ortega-Mora LM, Hemphill A. de Sousa MCF, et al. Among authors: hanggeli kpa. Int J Parasitol Drugs Drug Resist. 2024 Aug;25:100553. doi: 10.1016/j.ijpddr.2024.100553. Epub 2024 Jun 19. Int J Parasitol Drugs Drug Resist. 2024. PMID: 38917582 Free PMC article.
In vitro and in vivo activities of a trithiolato-diRuthenium complex conjugated with sulfadoxine against the apicomplexan parasite Toxoplasma gondii.
Boubaker G, Bernal A, Vigneswaran A, Imhof D, de Sousa MCF, Hänggeli KPA, Haudenschild N, Furrer J, Păunescu E, Desiatkina O, Hemphill A. Boubaker G, et al. Among authors: hanggeli kpa. Int J Parasitol Drugs Drug Resist. 2024 Aug;25:100544. doi: 10.1016/j.ijpddr.2024.100544. Epub 2024 Apr 27. Int J Parasitol Drugs Drug Resist. 2024. PMID: 38703737 Free PMC article.
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice.
Schlange C, Müller J, Imhof D, Hänggeli KPA, Boubaker G, Ortega-Mora LM, Wong HN, Haynes RK, Van Voorhis WC, Hemphill A. Schlange C, et al. Among authors: hanggeli kpa. Exp Parasitol. 2023 Dec;255:108655. doi: 10.1016/j.exppara.2023.108655. Epub 2023 Nov 18. Exp Parasitol. 2023. PMID: 37981259 Free PMC article.
Immunization with a Multivalent Listeria monocytogenes Vaccine Leads to a Strong Reduction in Vertical Transmission and Cerebral Parasite Burden in Pregnant and Non-Pregnant Mice Infected with Neospora caninum.
Imhof D, Pownall W, Hänggeli KPA, Monney C, Román LR, Ortega-Mora LM, Forterre F, Oevermann A, Hemphill A. Imhof D, et al. Among authors: hanggeli kpa. Vaccines (Basel). 2023 Jan 11;11(1):156. doi: 10.3390/vaccines11010156. Vaccines (Basel). 2023. PMID: 36680001 Free PMC article.