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Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase.
Zmudzinski M, Rut W, Olech K, Granda J, Giurg M, Burda-Grabowska M, Kaleta R, Zgarbova M, Kasprzyk R, Zhang L, Sun X, Lv Z, Nayak D, Kesik-Brodacka M, Olsen SK, Weber J, Hilgenfeld R, Jemielity J, Drag M. Zmudzinski M, et al. Among authors: drag m. Sci Rep. 2023 Jun 6;13(1):9161. doi: 10.1038/s41598-023-35907-w. Sci Rep. 2023. PMID: 37280236 Free PMC article.
Betulin and Its Derivatives Reduce Inflammation and COX-2 Activity in Macrophages.
Szlasa W, Ślusarczyk S, Nawrot-Hadzik I, Abel R, Zalesińska A, Szewczyk A, Sauer N, Preissner R, Saczko J, Drąg M, Poręba M, Daczewska M, Kulbacka J, Drąg-Zalesińska M. Szlasa W, et al. Among authors: drag zalesinska m, drag m. Inflammation. 2023 Apr;46(2):573-583. doi: 10.1007/s10753-022-01756-4. Epub 2022 Oct 25. Inflammation. 2023. PMID: 36282372 Free PMC article.
Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.
Mahoney MW, Helander J, Kooner AS, Norman M, Damalanka VC, De Bona P, Kasperkiewicz P, Rut W, Poreba M, Kashipathy MM, Battaile KP, Lovell S, O'Donoghue AJ, Craik CS, Drag M, Janetka JW. Mahoney MW, et al. Among authors: drag m. Protein Sci. 2024 Aug;33(8):e5110. doi: 10.1002/pro.5110. Protein Sci. 2024. PMID: 39073183
The tick Ixodes scapularis has five different GPCRs specifically activated by ACP (adipokinetic hormone/corazonin-related peptide).
Hauser F, Stebegg M, Al-Ribaty T, Petersen LB, Møller M, Drag MH, Sigurdsson HH, Vilhelm MJ, Thygesen G, Grimmelikhuijzen CJP. Hauser F, et al. Among authors: drag mh. Biochem Biophys Res Commun. 2024 Jul 12;717:149992. doi: 10.1016/j.bbrc.2024.149992. Epub 2024 May 3. Biochem Biophys Res Commun. 2024. PMID: 38714013 Free article.
183 results