Khojasteh SC - Search Results

1

Discovery of Unprecedented Human Stercobilin Conjugates.

Cho S, Cheruzel L, Cai J, Wrigley SK, Gemmell RT, Kokubun T, Steele JCP, Salphati L, Zhang D, Khojasteh SC. Cho S, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2024 Aug 14;52(9):981-987. doi: 10.1124/dmd.124.001725. Drug Metab Dispos. 2024. PMID: 38991780

2

Bioactivation of α,β-Unsaturated Carboxylic Acids Through Acyl Glucuronidation.

Mulder T, Bobba S, Johnson K, Grandner JM, Wang W, Zhang C, Cai J, Choo EF, Khojasteh SC, Zhang D. Mulder T, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2020 Sep;48(9):819-829. doi: 10.1124/dmd.120.000096. Epub 2020 Jul 2. Drug Metab Dispos. 2020. PMID: 32616543

3

Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in Glucuronidation.

Wang S, Ma S, Chen E, Wang J, Le H, Hanlon SP, Binder M, Lee W, Khojasteh SC, Salphati L. Wang S, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2023 Jul;51(7):862-872. doi: 10.1124/dmd.123.001289. Epub 2023 Apr 14. Drug Metab Dispos. 2023. PMID: 37059472

4

Mass Balance, Metabolic Pathways, Absolute Bioavailability, and Pharmacokinetics of Giredestrant in Healthy Subjects.

Kshirsagar S, Chen YC, Yu J, Gates MR, Kawakatsu S, Khojasteh SC, Ma S, Musib L, Malhi V, Osaghae U, Wang J, Cho S, Tang YT, Zhang D, Zhao W, De Bruyn T. Kshirsagar S, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2024 Jul 16;52(8):847-857. doi: 10.1124/dmd.124.001688. Drug Metab Dispos. 2024. PMID: 38834357

5

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.

Fan PW, Zhang D, Halladay JS, Driscoll JP, Khojasteh SC. Fan PW, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2016 Aug;44(8):1253-61. doi: 10.1124/dmd.116.070169. Epub 2016 Apr 26. Drug Metab Dispos. 2016. PMID: 27117704 Review.

6

Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates.

Zhang D, Yu SF, Ma Y, Xu K, Dragovich PS, Pillow TH, Liu L, Del Rosario G, He J, Pei Z, Sadowsky JD, Erickson HK, Hop CE, Khojasteh SC. Zhang D, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2016 Sep;44(9):1517-23. doi: 10.1124/dmd.116.070631. Epub 2016 Jul 14. Drug Metab Dispos. 2016. PMID: 27417182 Free PMC article.

7

Antibody Drug Conjugates Differentiate Uptake and DNA Alkylation of Pyrrolobenzodiazepines in Tumors from Organs of Xenograft Mice.

Ma Y, Khojasteh SC, Hop CE, Erickson HK, Polson A, Pillow TH, Yu SF, Wang H, Dragovich PS, Zhang D. Ma Y, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2016 Dec;44(12):1958-1962. doi: 10.1124/dmd.116.073031. Epub 2016 Sep 28. Drug Metab Dispos. 2016. PMID: 27683653

8

Carfilzomib Is Not an Appropriate Payload of Antibody-Drug Conjugates Due to Rapid Inactivation by Lysosomal Enzymes.

Ma Y, Dela Cruz-Chuh J, Khojasteh SC, Dragovich PS, Pillow TH, Zhang D. Ma Y, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2019 Aug;47(8):884-889. doi: 10.1124/dmd.119.086595. Epub 2019 May 9. Drug Metab Dispos. 2019. PMID: 31072822

9

Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates.

Zhang D, Fourie-O'Donohue A, Dragovich PS, Pillow TH, Sadowsky JD, Kozak KR, Cass RT, Liu L, Deng Y, Liu Y, Hop CECA, Khojasteh SC. Zhang D, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2019 Oct;47(10):1156-1163. doi: 10.1124/dmd.118.086132. Epub 2019 May 13. Drug Metab Dispos. 2019. PMID: 31085544

10

Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.

Zhang D, Dragovich PS, Yu SF, Ma Y, Pillow TH, Sadowsky JD, Su D, Wang W, Polson A, Khojasteh SC, Hop CECA. Zhang D, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2019 Oct;47(10):1146-1155. doi: 10.1124/dmd.119.087023. Epub 2019 Jul 29. Drug Metab Dispos. 2019. PMID: 31358513

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