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TDP43 autoregulation gives rise to dominant negative isoforms that are tightly controlled by transcriptional and post-translational mechanisms.
Dykstra MM, Weskamp K, Gómez NB, Waksmacki J, Tank E, Glineburg MR, Snyder A, Pinarbasi E, Bekier M, Li X, Miller MR, Bai J, Shahzad S, Nedumaran N, Wieland C, Stewart C, Willey S, Grotewold N, McBride J, Moran JJ, Suryakumar AV, Lucas M, Tessier PM, Ward M, Todd PK, Barmada SJ. Dykstra MM, et al. Among authors: waksmacki j. Cell Rep. 2025 Jan 8;44(1):115113. doi: 10.1016/j.celrep.2024.115113. Online ahead of print. Cell Rep. 2025. PMID: 39792557 Free article.
Stress granule formation helps to mitigate neurodegeneration.
Glineburg MR, Yildirim E, Gomez N, Rodriguez G, Pak J, Li X, Altheim C, Waksmacki J, McInerney GM, Barmada SJ, Todd PK. Glineburg MR, et al. Among authors: waksmacki j. Nucleic Acids Res. 2024 Sep 9;52(16):9745-9759. doi: 10.1093/nar/gkae655. Nucleic Acids Res. 2024. PMID: 39106168 Free PMC article.
TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms.
Dykstra MM, Weskamp K, Gómez NB, Waksmacki J, Tank E, Glineburg MR, Snyder A, Pinarbasi E, Bekier M, Li X, Bai J, Shahzad S, Nedumaran J, Wieland C, Stewart C, Willey S, Grotewold N, McBride J, Moran JJ, Suryakumar AV, Lucas M, Tessier P, Ward M, Todd P, Barmada SJ. Dykstra MM, et al. Among authors: waksmacki j. bioRxiv [Preprint]. 2024 Jul 4:2024.07.02.601776. doi: 10.1101/2024.07.02.601776. bioRxiv. 2024. Update in: Cell Rep. 2025 Jan 8;44(1):115113. doi: 10.1016/j.celrep.2024.115113 PMID: 39005384 Free PMC article. Updated. Preprint.
Counter-regulation of RNA stability by UPF1 and TDP43.
Gomez N, Hsieh C, Li X, Dykstra M, Waksmacki J, Altheim C, Bechar Y, Klim J, Zaepfel B, Rothstein J, Tank EE, Barmada SJ. Gomez N, et al. Among authors: waksmacki j. bioRxiv [Preprint]. 2024 Feb 15:2024.01.31.578310. doi: 10.1101/2024.01.31.578310. bioRxiv. 2024. PMID: 38352350 Free PMC article. Preprint.