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535 results

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ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
Nixon-Abell J, Ruggeri FS, Qamar S, Herling TW, Czekalska MA, Shen Y, Wang G, King C, Fernandopulle MS, Sneideris T, Watson JL, Pillai VVS, Meadows W, Henderson JW, Chambers JE, Wagstaff JL, Williams SH, Coyle H, Lu Y, Zhang S, Marciniak SJ, Freund SMV, Derivery E, Ward ME, Vendruscolo M, Knowles TPJ, St George-Hyslop P. Nixon-Abell J, et al. Among authors: vendruscolo m. bioRxiv [Preprint]. 2023 Mar 24:2023.03.22.533832. doi: 10.1101/2023.03.22.533832. bioRxiv. 2023. PMID: 36993242 Free PMC article. Preprint.
AlphaFold2-based prediction of the co-condensation propensity of proteins.
Zhang S, Lim CM, Occhetta M, Vendruscolo M. Zhang S, et al. Among authors: vendruscolo m. Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2315005121. doi: 10.1073/pnas.2315005121. Epub 2024 Aug 12. Proc Natl Acad Sci U S A. 2024. PMID: 39133858 Free PMC article.
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
Horne RI, Andrzejewska EA, Alam P, Brotzakis ZF, Srivastava A, Aubert A, Nowinska M, Gregory RC, Staats R, Possenti A, Chia S, Sormanni P, Ghetti B, Caughey B, Knowles TPJ, Vendruscolo M. Horne RI, et al. Among authors: vendruscolo m. Nat Chem Biol. 2024 May;20(5):634-645. doi: 10.1038/s41589-024-01580-x. Epub 2024 Apr 17. Nat Chem Biol. 2024. PMID: 38632492 Free PMC article.
Estimation of Ligand Binding Free Energy Using Multi-eGO.
Stegani B, Scalone E, Toplek FB, Löhr T, Gianni S, Vendruscolo M, Capelli R, Camilloni C. Stegani B, et al. Among authors: vendruscolo m. J Chem Inf Model. 2025 Jan 13;65(1):351-362. doi: 10.1021/acs.jcim.4c01545. Epub 2024 Dec 31. J Chem Inf Model. 2025. PMID: 39737687
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.
Watamura N, Foiani MS, Bez S, Bourdenx M, Santambrogio A, Frodsham C, Camporesi E, Brinkmalm G, Zetterberg H, Patel S, Kamano N, Takahashi M, Rueda-Carrasco J, Katsouri L, Fowler S, Turkes E, Hashimoto S, Sasaguri H, Saito T, Islam AS, Benner S, Endo T, Kobayashi K, Ishida C, Vendruscolo M, Yamada M, Duff KE, Saido TC. Watamura N, et al. Among authors: vendruscolo m. Nat Neurosci. 2024 Dec 24. doi: 10.1038/s41593-024-01829-7. Online ahead of print. Nat Neurosci. 2024. PMID: 39719507
535 results