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Page 1
Rational correction of pathogenic conformational defects in HTRA1.
Beaufort N, Ingendahl L, Merdanovic M, Schmidt A, Podlesainski D, Richter T, Neumann T, Kuszner M, Vetter IR, Stege P, Burston SG, Filipovic A, Ruiz-Blanco YB, Bravo-Rodriguez K, Mieres-Perez J, Beuck C, Uebel S, Zobawa M, Schillinger J, Malik R, Todorov-Völgyi K, Rey J, Roberti A, Hagemeier B, Wefers B, Müller SA, Wurst W, Sanchez-Garcia E, Zimmermann A, Hu XY, Clausen T, Huber R, Lichtenthaler SF, Schmuck C, Giese M, Kaiser M, Ehrmann M, Dichgans M. Beaufort N, et al. Nat Commun. 2024 Jul 16;15(1):5944. doi: 10.1038/s41467-024-49982-8. Nat Commun. 2024. PMID: 39013852 Free PMC article.
Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease.
Dichgans M, Malik R, Beaufort N, Tanaka K, Georgakis M, He Y, Koido M, Terao C, Anderson C, Kamatani Y. Dichgans M, et al. Among authors: beaufort n. Res Sq [Preprint]. 2023 Nov 7:rs.3.rs-3523612. doi: 10.21203/rs.3.rs-3523612/v1. Res Sq. 2023. Update in: Nat Cardiovasc Res. 2024 Jun;3(6):701-713. doi: 10.1038/s44161-024-00475-3 PMID: 37986915 Free PMC article. Updated. Preprint.
Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging.
Todorov-Völgyi K, González-Gallego J, Müller SA, Beaufort N, Malik R, Schifferer M, Todorov MI, Crusius D, Robinson S, Schmidt A, Körbelin J, Bareyre F, Ertürk A, Haass C, Simons M, Paquet D, Lichtenthaler SF, Dichgans M. Todorov-Völgyi K, et al. Among authors: beaufort n. Nat Aging. 2024 Apr;4(4):595-612. doi: 10.1038/s43587-024-00598-z. Epub 2024 Mar 22. Nat Aging. 2024. PMID: 38519806
IKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses.
Asare Y, Shnipova M, Živković L, Schlegl C, Tosato F, Aronova A, Brandhofer M, Strohm L, Beaufort N, Malik R, Weber C, Bernhagen J, Dichgans M. Asare Y, et al. Among authors: beaufort n. Signal Transduct Target Ther. 2022 Oct 19;7(1):355. doi: 10.1038/s41392-022-01189-3. Signal Transduct Target Ther. 2022. PMID: 36257930 Free PMC article. No abstract available.
Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates.
Zellner A, Müller SA, Lindner B, Beaufort N, Rozemuller AJM, Arzberger T, Gassen NC, Lichtenthaler SF, Kuster B, Haffner C, Dichgans M. Zellner A, et al. Among authors: beaufort n. Acta Neuropathol Commun. 2022 Jan 24;10(1):6. doi: 10.1186/s40478-021-01303-6. Acta Neuropathol Commun. 2022. PMID: 35074002 Free PMC article.
Stroke Genetics: Turning Discoveries into Clinical Applications.
Dichgans M, Beaufort N, Debette S, Anderson CD. Dichgans M, et al. Among authors: beaufort n. Stroke. 2021 Aug;52(9):2974-2982. doi: 10.1161/STROKEAHA.121.032616. Epub 2021 Aug 17. Stroke. 2021. PMID: 34399583 Free PMC article. Review.
Common coding variant in SERPINA1 increases the risk for large artery stroke.
Malik R, Dau T, Gonik M, Sivakumar A, Deredge DJ, Edeleva EV, Götzfried J, van der Laan SW, Pasterkamp G, Beaufort N, Seixas S, Bevan S, Lincz LF, Holliday EG, Burgess AI, Rannikmäe K, Minnerup J, Kriebel J, Waldenberger M, Müller-Nurasyid M, Lichtner P, Saleheen D; International Stroke Genetics Consortium; Rothwell PM, Levi C, Attia J, Sudlow CL, Braun D, Markus HS, Wintrode PL, Berger K, Jenne DE, Dichgans M. Malik R, et al. Among authors: beaufort n. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3613-3618. doi: 10.1073/pnas.1616301114. Epub 2017 Mar 6. Proc Natl Acad Sci U S A. 2017. PMID: 28265093 Free PMC article.
32 results