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Page 1
Rational correction of pathogenic conformational defects in HTRA1.
Beaufort N, Ingendahl L, Merdanovic M, Schmidt A, Podlesainski D, Richter T, Neumann T, Kuszner M, Vetter IR, Stege P, Burston SG, Filipovic A, Ruiz-Blanco YB, Bravo-Rodriguez K, Mieres-Perez J, Beuck C, Uebel S, Zobawa M, Schillinger J, Malik R, Todorov-Völgyi K, Rey J, Roberti A, Hagemeier B, Wefers B, Müller SA, Wurst W, Sanchez-Garcia E, Zimmermann A, Hu XY, Clausen T, Huber R, Lichtenthaler SF, Schmuck C, Giese M, Kaiser M, Ehrmann M, Dichgans M. Beaufort N, et al. Among authors: mieres perez j. Nat Commun. 2024 Jul 16;15(1):5944. doi: 10.1038/s41467-024-49982-8. Nat Commun. 2024. PMID: 39013852 Free PMC article.
Multivalent Molecular Tweezers Disrupt the Essential NDC80 Interaction with Microtubules.
Neblik J, Kirupakaran A, Beuck C, Mieres-Perez J, Niemeyer F, Le MH, Telgheder U, Schmuck JF, Dudziak A, Bayer P, Sanchez-Garcia E, Westermann S, Schrader T. Neblik J, et al. Among authors: mieres perez j. J Am Chem Soc. 2023 Jul 19;145(28):15251-15264. doi: 10.1021/jacs.3c02186. Epub 2023 Jul 1. J Am Chem Soc. 2023. PMID: 37392180
The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties.
Olari LR, Bauer R, Gil Miró M, Vogel V, Cortez Rayas L, Groß R, Gilg A, Klevesath R, Rodríguez Alfonso AA, Kaygisiz K, Rupp U, Pant P, Mieres-Pérez J, Steppe L, Schäffer R, Rauch-Wirth L, Conzelmann C, Müller JA, Zech F, Gerbl F, Bleher J, Preising N, Ständker L, Wiese S, Thal DR, Haupt C, Jonker HRA, Wagner M, Sanchez-Garcia E, Weil T, Stenger S, Fändrich M, von Einem J, Read C, Walther P, Kirchhoff F, Spellerberg B, Münch J. Olari LR, et al. Among authors: mieres perez j. Cell Mol Life Sci. 2023 May 17;80(6):151. doi: 10.1007/s00018-023-04795-8. Cell Mol Life Sci. 2023. PMID: 37198527 Free PMC article.
Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses.
Weil T, Kirupakaran A, Le MH, Rebmann P, Mieres-Perez J, Issmail L, Conzelmann C, Müller JA, Rauch L, Gilg A, Wettstein L, Groß R, Read C, Bergner T, Pålsson SA, Uhlig N, Eberlein V, Wöll H, Klärner FG, Stenger S, Kümmerer BM, Streeck H, Fois G, Frick M, Braubach P, Spetz AL, Grunwald T, Shorter J, Sanchez-Garcia E, Schrader T, Münch J. Weil T, et al. Among authors: mieres perez j. JACS Au. 2022 Sep 6;2(9):2187-2202. doi: 10.1021/jacsau.2c00220. eCollection 2022 Sep 26. JACS Au. 2022. PMID: 36186568 Free PMC article.
An allosteric HTRA1-calpain 2 complex with restricted activation profile.
Rey J, Breiden M, Lux V, Bluemke A, Steindel M, Ripkens K, Möllers B, Bravo Rodriguez K, Boisguerin P, Volkmer R, Mieres-Perez J, Clausen T, Sanchez-Garcia E, Ehrmann M. Rey J, et al. Among authors: mieres perez j. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2113520119. doi: 10.1073/pnas.2113520119. Epub 2022 Mar 29. Proc Natl Acad Sci U S A. 2022. PMID: 35349341 Free PMC article.
Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers.
Malishev R, Salinas N, Gibson J, Eden AB, Mieres-Perez J, Ruiz-Blanco YB, Malka O, Kolusheva S, Klärner FG, Schrader T, Sanchez-Garcia E, Wang C, Landau M, Bitan G, Jelinek R. Malishev R, et al. Among authors: mieres perez j. Cell Chem Biol. 2021 Sep 16;28(9):1310-1320.e5. doi: 10.1016/j.chembiol.2021.03.013. Epub 2021 Apr 13. Cell Chem Biol. 2021. PMID: 33852903 Free PMC article.
24 results