Hu L - Search Results

1

8-l-Cystinyl Bis(1,8-diazaspiro[4.5]decane) as an Orally Bioavailable l-Cystine Crystallization Inhibitor for Cystinuria.

Hu L, Albanyan H, Yang J, Wang Y, Yang M, Tan X, Zhong X, Ward MD, Sahota A. Hu L, et al. ACS Med Chem Lett. 2024 Jun 6;15(7):1026-1031. doi: 10.1021/acsmedchemlett.4c00066. eCollection 2024 Jul 11. ACS Med Chem Lett. 2024. PMID: 39015267 Free PMC article.

2

Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents.

Abed DA, Goldstein M, Albanyan H, Jin H, Hu L. Abed DA, et al. Among authors: hu l. Acta Pharm Sin B. 2015 Jul;5(4):285-99. doi: 10.1016/j.apsb.2015.05.008. Epub 2015 Jul 2. Acta Pharm Sin B. 2015. PMID: 26579458 Free PMC article. Review.

3

l-Cystine Diamides as l-Cystine Crystallization Inhibitors for Cystinuria.

Hu L, Yang Y, Aloysius H, Albanyan H, Yang M, Liang JJ, Yu A, Shtukenberg A, Poloni LN, Kholodovych V, Tischfield JA, Goldfarb DS, Ward MD, Sahota A. Hu L, et al. J Med Chem. 2016 Aug 11;59(15):7293-8. doi: 10.1021/acs.jmedchem.6b00647. Epub 2016 Jul 26. J Med Chem. 2016. PMID: 27409142 Free PMC article.

4

Role of Molecular Recognition in l-Cystine Crystal Growth Inhibition.

Poloni LN, Zhu Z, Garcia-Vázquez N, Yu AC, Connors DM, Hu L, Sahota A, Ward MD, Shtukenberg AG. Poloni LN, et al. Among authors: hu l. Cryst Growth Des. 2017 May 3;17(5):2767-2781. doi: 10.1021/acs.cgd.7b00236. Epub 2017 Apr 13. Cryst Growth Des. 2017. PMID: 29234242 Free PMC article.

5

Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria.

Yang Y, Albanyan H, Lee S, Aloysius H, Liang JJ, Kholodovych V, Sahota A, Hu L. Yang Y, et al. Among authors: hu l. Bioorg Med Chem Lett. 2018 May 1;28(8):1303-1308. doi: 10.1016/j.bmcl.2018.03.024. Epub 2018 Mar 10. Bioorg Med Chem Lett. 2018. PMID: 29571572 Free PMC article.

6

Immunomodulators targeting the PD-1/PD-L1 protein-protein interaction: From antibodies to small molecules.

Yang J, Hu L. Yang J, et al. Among authors: hu l. Med Res Rev. 2019 Jan;39(1):265-301. doi: 10.1002/med.21530. Epub 2018 Sep 14. Med Res Rev. 2019. PMID: 30215856 Review.

7

Cystinuria: genetic aspects, mouse models, and a new approach to therapy.

Sahota A, Tischfield JA, Goldfarb DS, Ward MD, Hu L. Sahota A, et al. Among authors: hu l. Urolithiasis. 2019 Feb;47(1):57-66. doi: 10.1007/s00240-018-1101-7. Epub 2018 Dec 4. Urolithiasis. 2019. PMID: 30515543 Free PMC article. Review.

8

Design, Synthesis, Evaluation, and Structural Studies of C₂-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction.

Basu S, Yang J, Xu B, Magiera-Mularz K, Skalniak L, Musielak B, Kholodovych V, Holak TA, Hu L. Basu S, et al. Among authors: hu l. J Med Chem. 2019 Aug 8;62(15):7250-7263. doi: 10.1021/acs.jmedchem.9b00795. Epub 2019 Jul 25. J Med Chem. 2019. PMID: 31298541

9

Disrupting Crystal Growth through Molecular Recognition: Designer Therapies for Kidney Stone Prevention.

Shtukenberg AG, Hu L, Sahota A, Kahr B, Ward MD. Shtukenberg AG, et al. Among authors: hu l. Acc Chem Res. 2022 Feb 15;55(4):516-525. doi: 10.1021/acs.accounts.1c00631. Epub 2022 Jan 28. Acc Chem Res. 2022. PMID: 35088591 Free PMC article.

10

Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations.

Wang J, Lam D, Yang J, Hu L. Wang J, et al. Among authors: hu l. Med Chem Res. 2022;31(10):1647-1662. doi: 10.1007/s00044-022-02952-5. Epub 2022 Sep 1. Med Chem Res. 2022. PMID: 36065226 Free PMC article. Review.

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