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Page 1
Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach.
Alpizar-Sosa EA, Zimbres FM, Mantilla BS, Dickie EA, Wei W, Burle-Caldas GA, Filipe LNS, Van Bocxlaer K, Price HP, Ibarra-Meneses AV, Beaudry F, Fernandez-Prada C, Whitfield PD, Barrett MP, Denny PW. Alpizar-Sosa EA, et al. Among authors: dickie ea. ACS Infect Dis. 2024 Aug 9;10(8):2913-2928. doi: 10.1021/acsinfecdis.4c00284. Epub 2024 Jul 18. ACS Infect Dis. 2024. PMID: 39023360 Free PMC article.
Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase.
Mina JGM, Charlton RL, Alpizar-Sosa E, Escrivani DO, Brown C, Alqaisi A, Borsodi MPG, Figueiredo CP, de Lima EV, Dickie EA, Wei W, Coutinho-Silva R, Merritt A, Smith TK, Barrett MP, Rossi-Bergmann B, Denny PW, Steel PG. Mina JGM, et al. Among authors: dickie ea. ACS Infect Dis. 2021 Jan 8;7(1):47-63. doi: 10.1021/acsinfecdis.0c00546. Epub 2020 Dec 8. ACS Infect Dis. 2021. PMID: 33291887 Free PMC article.
Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response.
Alpizar-Sosa EA, Ithnin NRB, Wei W, Pountain AW, Weidt SK, Donachie AM, Ritchie R, Dickie EA, Burchmore RJS, Denny PW, Barrett MP. Alpizar-Sosa EA, et al. Among authors: dickie ea. PLoS Negl Trop Dis. 2022 Sep 28;16(9):e0010779. doi: 10.1371/journal.pntd.0010779. eCollection 2022 Sep. PLoS Negl Trop Dis. 2022. PMID: 36170238 Free PMC article.
Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.
Steketee PC, Dickie EA, Iremonger J, Crouch K, Paxton E, Jayaraman S, Alfituri OA, Awuah-Mensah G, Ritchie R, Schnaufer A, Rowan T, de Koning HP, Gadelha C, Wickstead B, Barrett MP, Morrison LJ. Steketee PC, et al. Among authors: dickie ea. PLoS Pathog. 2021 Jul 26;17(7):e1009734. doi: 10.1371/journal.ppat.1009734. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34310651 Free PMC article.