Brabec V - Search Results

1

Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption.

Song H, Kostrhunova H, Cervinka J, Macpherson J, Malina J, Rajan T, Phillips R, Postings M, Shepherd S, Zhang X, Brabec V, Rogers NJ, Scott P. Song H, et al. Among authors: brabec v. Chem Sci. 2024 Jun 14;15(28):11029-11037. doi: 10.1039/d4sc02541e. eCollection 2024 Jul 17. Chem Sci. 2024. PMID: 39027295 Free PMC article.

2

DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands.

Malina J, Hofr C, Maresca L, Natile G, Brabec V. Malina J, et al. Among authors: brabec v. Biophys J. 2000 Apr;78(4):2008-21. doi: 10.1016/S0006-3495(00)76748-8. Biophys J. 2000. PMID: 10733979 Free PMC article.

3

Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates.

Kostrhunova H, Brabec V. Kostrhunova H, et al. Among authors: brabec v. Biochemistry. 2000 Oct 17;39(41):12639-49. doi: 10.1021/bi000710h. Biochemistry. 2000. PMID: 11027144

The requirement for novel platinum antitumor drugs led to the concept of synthesis of novel platinum drugs based on targeting cisplatin to various carrier molecules. We have shown [Loskotova, H., and Brabec, V. (1999) Eur. J. Biochem. 266, 392-402] that attachment o …

The requirement for novel platinum antitumor drugs led to the concept of synthesis of novel platinum drugs based on targeting cisplatin to v …

4

Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media.

Malina J, Novakova O, Keppler BK, Alessio E, Brabec V. Malina J, et al. Among authors: brabec v. J Biol Inorg Chem. 2001 Apr;6(4):435-45. doi: 10.1007/s007750100223. J Biol Inorg Chem. 2001. PMID: 11372202

5

Recognition of major DNA adducts of enantiomeric cisplatin analogs by HMG box proteins and nucleotide excision repair of these adducts.

Malina J, Kasparkova J, Natile G, Brabec V. Malina J, et al. Among authors: brabec v. Chem Biol. 2002 May;9(5):629-38. doi: 10.1016/s1074-5521(02)00134-5. Chem Biol. 2002. PMID: 12031669

6

DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent.

Stehlikova K, Kostrhunova H, Kasparkova J, Brabec V. Stehlikova K, et al. Among authors: brabec v. Nucleic Acids Res. 2002 Jul 1;30(13):2894-8. doi: 10.1093/nar/gkf405. Nucleic Acids Res. 2002. PMID: 12087174 Free PMC article.

7

DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes.

Novakova O, Kasparkova J, Malina J, Natile G, Brabec V. Novakova O, et al. Among authors: brabec v. Nucleic Acids Res. 2003 Nov 15;31(22):6450-60. doi: 10.1093/nar/gkg863. Nucleic Acids Res. 2003. PMID: 14602903 Free PMC article.

8

Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents.

Kloster M, Kostrhunova H, Zaludova R, Malina J, Kasparkova J, Brabec V, Farrell N. Kloster M, et al. Among authors: brabec v. Biochemistry. 2004 Jun 22;43(24):7776-86. doi: 10.1021/bi030243e. Biochemistry. 2004. PMID: 15196020

9

Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent.

Delalande O, Malina J, Brabec V, Kozelka J. Delalande O, et al. Among authors: brabec v. Biophys J. 2005 Jun;88(6):4159-69. doi: 10.1529/biophysj.104.054650. Epub 2005 Apr 1. Biophys J. 2005. PMID: 15805172 Free PMC article.

10

DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins.

Malina J, Vojtiskova M, Brabec V, Diakos CI, Hambley TW. Malina J, et al. Among authors: brabec v. Biochem Biophys Res Commun. 2005 Jul 15;332(4):1034-41. doi: 10.1016/j.bbrc.2005.05.047. Biochem Biophys Res Commun. 2005. PMID: 15922304

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