Phillips R - Search Results

1

Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption.

Song H, Kostrhunova H, Cervinka J, Macpherson J, Malina J, Rajan T, Phillips R, Postings M, Shepherd S, Zhang X, Brabec V, Rogers NJ, Scott P. Song H, et al. Among authors: phillips r. Chem Sci. 2024 Jun 14;15(28):11029-11037. doi: 10.1039/d4sc02541e. eCollection 2024 Jul 17. Chem Sci. 2024. PMID: 39027295 Free PMC article.

2

Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification.

Song H, Rogers NJ, Allison SJ, Brabec V, Bridgewater H, Kostrhunova H, Markova L, Phillips RM, Pinder EC, Shepherd SL, Young LS, Zajac J, Scott P. Song H, et al. Chem Sci. 2019 Jul 18;10(37):8547-8557. doi: 10.1039/c9sc02651g. eCollection 2019 Oct 7. Chem Sci. 2019. PMID: 31803429 Free PMC article.

3

Anticancer metallohelices: nanomolar potency and high selectivity.

Kaner RA, Allison SJ, Faulkner AD, Phillips RM, Roper DI, Shepherd SL, Simpson DH, Waterfield NR, Scott P. Kaner RA, et al. Among authors: phillips rm. Chem Sci. 2016 Feb 1;7(2):951-958. doi: 10.1039/c5sc03677a. Epub 2015 Oct 26. Chem Sci. 2016. PMID: 28808525 Free PMC article.

4

Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds.

Song H, Rogers NJ, Brabec V, Clarkson GJ, Coverdale JPC, Kostrhunova H, Phillips RM, Postings M, Shepherd SL, Scott P. Song H, et al. Chem Commun (Camb). 2020 Jun 11;56(47):6392-6395. doi: 10.1039/d0cc02429e. Chem Commun (Camb). 2020. PMID: 32390012

5

Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo.

Song H, Allison SJ, Brabec V, Bridgewater HE, Kasparkova J, Kostrhunova H, Novohradsky V, Phillips RM, Pracharova J, Rogers NJ, Shepherd SL, Scott P. Song H, et al. Angew Chem Int Ed Engl. 2020 Aug 17;59(34):14677-14685. doi: 10.1002/anie.202006814. Epub 2020 Jul 7. Angew Chem Int Ed Engl. 2020. PMID: 32489012 Free PMC article.

6

Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis.

Lord RM, Hebden AJ, Pask CM, Henderson IR, Allison SJ, Shepherd SL, Phillips RM, McGowan PC. Lord RM, et al. Among authors: phillips rm. J Med Chem. 2015 Jun 25;58(12):4940-53. doi: 10.1021/acs.jmedchem.5b00455. Epub 2015 Jun 8. J Med Chem. 2015. PMID: 25906293 Free article.

7

Asymmetric triplex metallohelices with high and selective activity against cancer cells.

Faulkner AD, Kaner RA, Abdallah QM, Clarkson G, Fox DJ, Gurnani P, Howson SE, Phillips RM, Roper DI, Simpson DH, Scott P. Faulkner AD, et al. Nat Chem. 2014 Sep;6(9):797-803. doi: 10.1038/nchem.2024. Epub 2014 Aug 3. Nat Chem. 2014. PMID: 25143215

8

Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells.

Allison SJ, Cooke D, Davidson FS, Elliott PIP, Faulkner RA, Griffiths HBS, Harper OJ, Hussain O, Owen-Lynch PJ, Phillips RM, Rice CR, Shepherd SL, Wheelhouse RT. Allison SJ, et al. Among authors: phillips rm. Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9799-9804. doi: 10.1002/anie.201805510. Epub 2018 Jul 3. Angew Chem Int Ed Engl. 2018. PMID: 29863754

9

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands.

Allison SJ, Sadiq M, Baronou E, Cooper PA, Dunnill C, Georgopoulos NT, Latif A, Shepherd S, Shnyder SD, Stratford IJ, Wheelhouse RT, Willans CE, Phillips RM. Allison SJ, et al. Cancer Lett. 2017 Sep 10;403:98-107. doi: 10.1016/j.canlet.2017.04.041. Epub 2017 Jun 15. Cancer Lett. 2017. PMID: 28624622 Free article.

10

Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes.

Mohamed HA, Khuphe M, Boardman SJ, Shepherd S, Phillips RM, Thornton PD, Willans CE. Mohamed HA, et al. Among authors: phillips rm. RSC Adv. 2018 Mar 15;8(19):10474-10477. doi: 10.1039/c8ra00450a. eCollection 2018 Mar 13. RSC Adv. 2018. PMID: 35540495 Free PMC article.

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