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Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors.
Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, Schreiber C, Berger LM, Berger BT, Ehret TAL, Elson L, Lenz C, Saxena K, Müller S, Einav S, Knapp S, Hanke T. Gerninghaus J, et al. Among authors: knapp s. J Med Chem. 2024 Aug 8;67(15):12534-12552. doi: 10.1021/acs.jmedchem.4c00411. Epub 2024 Jul 19. J Med Chem. 2024. PMID: 39028937
Thermodynamics of HMGB1 interaction with duplex DNA.
Müller S, Bianchi ME, Knapp S. Müller S, et al. Among authors: knapp s. Biochemistry. 2001 Aug 28;40(34):10254-61. doi: 10.1021/bi0100900. Biochemistry. 2001. PMID: 11513603
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S. Fedorov O, et al. Among authors: knapp s. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. doi: 10.1073/pnas.0708800104. Epub 2007 Dec 11. Proc Natl Acad Sci U S A. 2007. PMID: 18077363 Free PMC article.
SH2 domains: modulators of nonreceptor tyrosine kinase activity.
Filippakopoulos P, Müller S, Knapp S. Filippakopoulos P, et al. Among authors: knapp s. Curr Opin Struct Biol. 2009 Dec;19(6):643-9. doi: 10.1016/j.sbi.2009.10.001. Epub 2009 Nov 18. Curr Opin Struct Biol. 2009. PMID: 19926274 Free PMC article. Review.
The (un)targeted cancer kinome.
Fedorov O, Müller S, Knapp S. Fedorov O, et al. Among authors: knapp s. Nat Chem Biol. 2010 Mar;6(3):166-169. doi: 10.1038/nchembio.297. Nat Chem Biol. 2010. PMID: 20154661 No abstract available.
Bromodomains as therapeutic targets.
Muller S, Filippakopoulos P, Knapp S. Muller S, et al. Among authors: knapp s. Expert Rev Mol Med. 2011 Sep 13;13:e29. doi: 10.1017/S1462399411001992. Expert Rev Mol Med. 2011. PMID: 21933453 Free PMC article. Review.
1,314 results