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Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors.
Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, Schreiber C, Berger LM, Berger BT, Ehret TAL, Elson L, Lenz C, Saxena K, Müller S, Einav S, Knapp S, Hanke T. Gerninghaus J, et al. Among authors: lenz c. J Med Chem. 2024 Aug 8;67(15):12534-12552. doi: 10.1021/acs.jmedchem.4c00411. Epub 2024 Jul 19. J Med Chem. 2024. PMID: 39028937
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, Schreiber C, Berger LM, Berger BT, Ehret TAL, Elson L, Lenz C, Saxena K, Müller S, Einav S, Knapp S, Hanke T. Gerninghaus J, et al. Among authors: lenz c. bioRxiv [Preprint]. 2024 Feb 18:2024.02.18.580805. doi: 10.1101/2024.02.18.580805. bioRxiv. 2024. Update in: J Med Chem. 2024 Aug 8;67(15):12534-12552. doi: 10.1021/acs.jmedchem.4c00411. PMID: 38405908 Free PMC article. Updated. Preprint.
Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study.
Bienek O, Allott K, Antonucci L, Bertolino A, Bonivento C, Borgwardt S, Brambilla P, Chisholm K, Dannlowski U, Lichtenstein TK, Kambeitz J, Kambeitz-Ilankovic L, Koutsouleris N, Lencer R, Griffiths SL, Maggioni E, Meisenzahl E, Pantelis C, Rosen M, Ruhrmann S, Salokangas RKR, Stainton A, Surmann M, Upthegrove R, Wenzel J, Wood SJ, Romer G, Müller JM; PRONIA Consortium. Bienek O, et al. Eur Child Adolesc Psychiatry. 2024 Nov 6. doi: 10.1007/s00787-024-02599-0. Online ahead of print. Eur Child Adolesc Psychiatry. 2024. PMID: 39503777
Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Δ/+ mice hearts.
Foo B, Amedei H, Kaur S, Jaawan S, Boshnakovska A, Gall T, de Boer RA, Silljé HHW, Urlaub H, Rehling P, Lenz C, Lehnart SE. Foo B, et al. Among authors: lenz c. PLoS One. 2024 Oct 24;19(10):e0311203. doi: 10.1371/journal.pone.0311203. eCollection 2024. PLoS One. 2024. PMID: 39446877 Free PMC article.
The Lateral Corticospinal Tract Sign: An MRI Marker for Amyotrophic Lateral Sclerosis.
Wendebourg MJ, Kesenheimer E, Sander L, Weigel M, Weidensteiner C, Haas T, Madoerin P, Diebold M, Deigendesch N, Neuhaus D, Naumann N, Neuwirth C, Braun N, Weber M, Granziera C, Scheurer E, Lenz C, Schweikert K, Sinnreich M, Lieb J, Bieri O, Schlaeger R. Wendebourg MJ, et al. Among authors: lenz c. Radiology. 2024 Sep;312(3):e231630. doi: 10.1148/radiol.231630. Radiology. 2024. PMID: 39287519
386 results