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Page 1
Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease.
Beckman D, Diniz GB, Ott S, Hobson B, Chaudhari AJ, Muller S, Chu Y, Takano A, Schwarz AJ, Yeh CL, McQuade P, Chakrabarty P, Kanaan NM, Quinton MS, Simen AA, Kordower JH, Morrison JH. Beckman D, et al. Among authors: mcquade p. Alzheimers Dement. 2024 Aug;20(8):5198-5219. doi: 10.1002/alz.13868. Epub 2024 Jun 21. Alzheimers Dement. 2024. PMID: 39030748 Free PMC article.
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, Capell A, Davis SS, de Weerd L, Dugas JC, Duque J, Earr T, Gadkar K, Giese T, Gill A, Gnörich J, Ha C, Kannuswamy M, Kim DJ, Kunte ST, Kunze LH, Lac D, Lechtenberg K, Leung AW, Liang CC, Lopez I, McQuade P, Modi A, Torres VO, Nguyen HN, Pesämaa I, Propson N, Reich M, Robles-Colmenares Y, Schlepckow K, Slemann L, Solanoy H, Suh JH, Thorne RG, Vieira C, Wind-Mark K, Xiong K, Zuchero YJY, Diaz D, Dennis MS, Huang F, Scearce-Levie K, Watts RJ, Haass C, Lewcock JW, Di Paolo G, Brendel M, Sanchez PE, Monroe KM. van Lengerich B, et al. Among authors: mcquade p. Nat Neurosci. 2023 Mar;26(3):416-429. doi: 10.1038/s41593-022-01240-0. Epub 2023 Jan 12. Nat Neurosci. 2023. PMID: 36635496 Free PMC article.
Longitudinal imaging of therapeutic enzyme expression after gene therapy for Fabry disease using positron emission tomography and the radiotracer [18F]AGAL.
Kaittanis C, Teceno T, Knight A, Petibon Y, Sandoval P, Cohen L, Ahn SH, Belanger AP, Clark LM, Nguyen QD, Ruangsiriluk W, Mukherji S, Constantinescu CC, Amenta AL, Narayanan S, Deshpande M, Islam R, Yuan S, McQuade P, Winkelmann CT, Lohith TG. Kaittanis C, et al. Among authors: mcquade p. Mol Ther. 2024 Nov 19:S1525-0016(24)00748-2. doi: 10.1016/j.ymthe.2024.11.021. Online ahead of print. Mol Ther. 2024. PMID: 39563031 Free article.
Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators.
Perkins JJ, McQuade P, Bungard CJ, Diamond TL, Gantert LT, Gotter AL, Hanney B, Hills ID, Hurzy DM, Joshi A, Kern JT, Schlegel KS, Manikowski JJ, Meng Z, O'Brien JA, Roecker AJ, Smith SM, Uslaner JM, Hostetler E, Meissner RS. Perkins JJ, et al. Among authors: mcquade p. ACS Med Chem Lett. 2023 Jun 13;14(7):986-992. doi: 10.1021/acsmedchemlett.3c00175. eCollection 2023 Jul 13. ACS Med Chem Lett. 2023. PMID: 37465306 Free PMC article.
Design, Synthesis, and Evaluation of [18F]T-914 as a Novel Positron-Emission Tomography Tracer for Lysine-Specific Demethylase 1.
Matsuda S, Hattori Y, Matsumiya K, McQuade P, Yamashita T, Aida J, Sandiego CM, Gouasmat A, Carroll VM, Barret O, Tamagnan G, Koike T, Kimura H. Matsuda S, et al. Among authors: mcquade p. J Med Chem. 2021 Sep 9;64(17):12680-12690. doi: 10.1021/acs.jmedchem.1c00653. Epub 2021 Aug 23. J Med Chem. 2021. PMID: 34423983 Free article.
In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1.
Rubins DJ, Meng X, McQuade P, Klimas M, Getty K, Lin SA, Connolly BM, O'Malley SS, Haley H, Purcell M, Gantert L, Holahan M, Lindgren J, Eklund P, Ekblad C, Frejd FY, Hostetler ED, González Trotter DE, Evelhoch JL. Rubins DJ, et al. Among authors: mcquade p. Mol Imaging Biol. 2021 Apr;23(2):241-249. doi: 10.1007/s11307-020-01544-2. Epub 2020 Oct 23. Mol Imaging Biol. 2021. PMID: 33098025
Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.
Tong L, Li W, Lo MM, Gao X, Wai JM, Rudd M, Tellers D, Joshi A, Zeng Z, Miller P, Salinas C, Riffel K, Haley H, Purcell M, Holahan M, Gantert L, Schubert JW, Jones K, Mulhearn J, Egbertson M, Meng Z, Hanney B, Gomez R, Harrison ST, McQuade P, Bueters T, Uslaner J, Morrow J, Thomson F, Kong J, Liao J, Selyutin O, Bao J, Hastings NB, Agrawal S, Magliaro BC, Monsma FJ Jr, Smith MD, Risso S, Hesk D, Hostetler E, Mazzola R. Tong L, et al. Among authors: mcquade p. J Med Chem. 2020 Mar 12;63(5):2411-2425. doi: 10.1021/acs.jmedchem.9b01406. Epub 2020 Mar 3. J Med Chem. 2020. PMID: 32101422 Free article.
42 results