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Chlamydia trachomatis induces low-frequency, sustained CD4 T cell responses in most women, predominantly targeting chlamydial protease-like activity factor, CPAF.
Li Y, Warren JA, Poston TB, Clutton G, Shaw FR, Conrad SZ, Xu Y, Zheng X, Yount KS, O'Connell CM, Wiesenfeld HC, Darville T, Goonetilleke N. Li Y, et al. Among authors: poston tb. J Infect Dis. 2024 Sep 9:jiae443. doi: 10.1093/infdis/jiae443. Online ahead of print. J Infect Dis. 2024. PMID: 39250505
Intranasal immunization with CPAF combined with ADU-S100 induces an effector CD4 T cell response and reduces bacterial burden following intravaginal infection with Chlamydia muridarum.
Poston TB, Girardi J, Kim M, Zwarycz P, Polson AG, Yount KS, Hanlan C, Jaras Salas I, Lammert SM, Arroyo D, Bruno T, Wu M, Rozzelle J, Fairman J, Esser-Kahn AP, Darville T. Poston TB, et al. Vaccine. 2025 Jan 1;43(Pt 1):126526. doi: 10.1016/j.vaccine.2024.126526. Epub 2024 Nov 12. Vaccine. 2025. PMID: 39536454 Free article.
Comparable Genital Tract Infection, Pathology, and Immunity in Rhesus Macaques Inoculated with Wild-Type or Plasmid-Deficient Chlamydia trachomatis Serovar D.
Qu Y, Frazer LC, O'Connell CM, Tarantal AF, Andrews CW Jr, O'Connor SL, Russell AN, Sullivan JE, Poston TB, Vallejo AN, Darville T. Qu Y, et al. Among authors: poston tb. Infect Immun. 2015 Oct;83(10):4056-67. doi: 10.1128/IAI.00841-15. Epub 2015 Jul 27. Infect Immun. 2015. PMID: 26216426 Free PMC article.
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