Roh EJ - Search Results

1

Exploring the sedative properties of natural molecules from hop cones (Humulus lupulus) as promising natural anxiolytics through GABA receptors and the human serotonin transporter.

Belal A, Elballal MS, Al-Karmalawy AA, Hassan AHE, Roh EJ, Ghoneim MM, Ali MAM, Obaidullah AJ, Alotaibi JM, Shaaban S, Elanany MA. Belal A, et al. Among authors: roh ej. Front Chem. 2024 Jul 10;12:1425485. doi: 10.3389/fchem.2024.1425485. eCollection 2024. Front Chem. 2024. PMID: 39050372 Free PMC article.

2

Integrating computational methods guided the discovery of phytochemicals as potential Pin1 inhibitors for cancer: pharmacophore modeling, molecular docking, MM-GBSA calculations and molecular dynamics studies.

Alzain AA, Elbadwi FA, Shoaib TH, Sherif AE, Osman W, Ashour A, Mohamed GA, Ibrahim SRM, Roh EJ, Hassan AHE. Alzain AA, et al. Among authors: roh ej. Front Chem. 2024 Jan 22;12:1339891. doi: 10.3389/fchem.2024.1339891. eCollection 2024. Front Chem. 2024. PMID: 38318109 Free PMC article.

3

Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small library.

Elkamhawy A, Paik S, Hassan AHE, Lee YS, Roh EJ. Elkamhawy A, et al. Among authors: roh ej. Bioorg Chem. 2017 Dec;75:393-405. doi: 10.1016/j.bioorg.2017.10.009. Epub 2017 Nov 5. Bioorg Chem. 2017. PMID: 29102722

4

Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds.

Farag AK, Hassan AHE, Ahn BS, Park KD, Roh EJ. Farag AK, et al. Among authors: roh ej. J Enzyme Inhib Med Chem. 2020 Dec;35(1):311-324. doi: 10.1080/14756366.2019.1699554. J Enzyme Inhib Med Chem. 2020. PMID: 31809612 Free PMC article.

5

Diarylurea derivatives comprising 2,4-diarylpyrimidines: Discovery of novel potential anticancer agents via combined failed-ligands repurposing and molecular hybridization approaches.

Farag AK, Hassan AHE, Chung KS, Lee JH, Gil HS, Lee KT, Roh EJ. Farag AK, et al. Among authors: roh ej. Bioorg Chem. 2020 Oct;103:104121. doi: 10.1016/j.bioorg.2020.104121. Epub 2020 Jul 22. Bioorg Chem. 2020. PMID: 32745753

6

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.

Elkamhawy A, Park JE, Hassan AHE, Ra H, Pae AN, Lee J, Park BG, Moon B, Park HM, Roh EJ. Elkamhawy A, et al. Among authors: roh ej. Eur J Med Chem. 2017 Mar 10;128:56-69. doi: 10.1016/j.ejmech.2016.12.057. Epub 2016 Dec 29. Eur J Med Chem. 2017. PMID: 28152427

7

Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease.

Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Park BG, Roh EJ. Elkamhawy A, et al. Among authors: roh ej. Eur J Med Chem. 2018 Jan 20;144:529-543. doi: 10.1016/j.ejmech.2017.12.045. Epub 2017 Dec 14. Eur J Med Chem. 2018. PMID: 29288949

8

Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease.

Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ. Elkamhawy A, et al. Among authors: roh ej. Eur J Med Chem. 2018 Sep 5;157:268-278. doi: 10.1016/j.ejmech.2018.07.068. Epub 2018 Jul 31. Eur J Med Chem. 2018. PMID: 30098482

9

First-in-class DAPK1/CSF1R dual inhibitors: Discovery of 3,5-dimethoxy-N-(4-(4-methoxyphenoxy)-2-((6-morpholinopyridin-3-yl)amino)pyrimidin-5-yl)benzamide as a potential anti-tauopathies agent.

Farag AK, Hassan AHE, Jeong H, Kwon Y, Choi JG, Oh MS, Park KD, Kim YK, Roh EJ. Farag AK, et al. Among authors: roh ej. Eur J Med Chem. 2019 Jan 15;162:161-175. doi: 10.1016/j.ejmech.2018.10.057. Epub 2018 Nov 2. Eur J Med Chem. 2019. PMID: 30445265

10

EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor.

Elkamhawy A, Hassan AHE, Paik S, Sup Lee Y, Lee HH, Shin JS, Lee KT, Roh EJ. Elkamhawy A, et al. Among authors: roh ej. Bioorg Chem. 2019 May;86:112-118. doi: 10.1016/j.bioorg.2019.01.017. Epub 2019 Jan 12. Bioorg Chem. 2019. PMID: 30685642

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